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Cited by 23Treatment of Major DepressionSleep and related disordersSleep and Wakefulness Research

Reboxetine Induces Similar Sleep-EEG Changes Like SSRI’s in Patients with Depression

E., Kuenzel H., H., Murck, K., Held, M., Ziegenbein, A., Steiger·2004·Pharmacopsychiatry
DOI 10.1055/s-2004-827242
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Abstract

Background Reboxetine is a novel selective noradrenaline reuptake inhibitor. The antidepressive properties of the substance are established. Methods The influence of reboxetine on the sleep-EEG of eight patients with depression HAMD (mean +/- SD) 19.7 +/- 1.5 (5 women, 3 men; age range 31 to 75 years) was investigated. Sleep EEG was examined twice. The first examination was performed before starting active medication. The second examination was subsequently performed when patients received 8 to 10 mg reboxetine per day. Results Conventional sleep-EEG analysis showed a significant increase in intermittent wakefulness and sleep stage 2 and a decrease in sleep efficiency and REM time. Under reboxetine no significant changes were observed in sleep-EEG spectral analysis. Conclusion Our results indicate, that reboxetine induces sleep-EEG changes similar to those after selective serotonin reuptake inhibitors (SSRI's) by increasing intermittent wakefulness and decreasing REM time.

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  • Nocturnal disturbance and reduced sleep efficiency were found with reboxetine (8-10mg) in 8 depressed patients.

    “No RCTs were found in the systematic review, but one uncontrolled study showed evidence of transient sleep disruption, but persistent REM suppression, with 2mg (b.d.) of reboxetine in 12 dysthymic patients (Ferini-Strambi et al., 2004), and (Kuenzel et al., 2004) found nocturnal disturbance and reduced sleep efficiency with reboxetine (8-10mg) in 8 depressed patients.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Kuenzel et al., 2004

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Authors
E., K. H., H., M., K., H., M., Z., & A., S.
Venue
Pharmacopsychiatry
Publisher
Georg Thieme Verlag KG
Published
2004-09
Volume
37
Issue
5
Pages
193-195
ISSN
  • 0176-3679 (ISSN-L)
  • 1439-0795
DOI
10.1055/s-2004-827242
OpenAlex
W2066574561
Cited by
23
References
0
Citations by year
2021: 1 · 2019: 1 · 2016: 2 · 2015: 3 · 2013: 3 · 2012: 1
FWCI
1.32
Type
journal article
Language
de
Open access
closed
Locations
  • Pharmacopsychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
reboxetine, sleep EEG, depression, selective noradrenaline reuptake inhibitors, selective serotonin reuptake inhibitors, REM sleep, sleep efficiency, stage 2 sleep, antidepressant effects on sleep
MeSH terms
Reboxetine, Adult, Aged, Major Depressive Disorder, Electroencephalography, Female, Fluoxetine, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Morpholines, Sleep Stages, Wakefulness, Selective Serotonin Reuptake Inhibitors, Adrenergic Uptake Inhibitors

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