A review of the adverse effects and safety of noradrenergic antidepressants
Abstract
There are a variety of noradrenergic antidepressants available, most of which act by inhibiting neuronal noradrenaline re-uptake, although few drugs are specific for this action. Where drugs have numerous actions the adverse effects of noradrenaline reuptake may be difficult to isolate, although in this respect the adverse effects of reboxetine, a specific noradrenaline re-uptake inhibitor, are illuminating. Noradrenergic antidepressants typically cause minor changes in blood and heart rate, sweating and insomnia. Other pharmacological actions shown by non-specific antidepressants may act to worsen or mitigate these adverse effects. Noradrenergic drugs are less likely than selective serotonin reuptake inhibitors (SSRIs) to cause sexual dysfunction but more likely to cause urinary hesitancy. Doubts remain over the relative propensity for antidepressants with different modes of action to cause diabetes and hyponatraemia. Noradrenergic actions do not seem to confer a risk of death in overdose.
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Safety and tolerability concerns related to newer generation antidepressants including SSRIs and SNRIs have increased with recent research.
“However, safety and tolerability concerns related to the newer generation of antidepressants including SSRIs and selective serotonin-norepinephrine reuptake inhibitors (SNRIs) have increased with recent research.34”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [3]
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BindingDB Entry 50001820: Structural insights into serotonin receptor ligands polypharmacology.
BindingDB (2020) · UC San Diego · doi:10.7270/q2w098h4
- Authors
- Whiskey, E., & Taylor, D.
- Affiliations
- South London and Maudsley NHS Foundation Trust (GB)
- King's College London (GB)
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2013-06-19
- Volume
- 27
- Issue
- 8
- Pages
- 732-739
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W1998328102
- Cited by
- 64
- References
- 107
- Citations by year
- 2024: 9 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 1
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- noradrenergic antidepressants, adverse drug reactions, drug safety, norepinephrine reuptake inhibition, reboxetine, sexual dysfunction, urinary hesitancy, diabetes risk, hyponatremia, drug overdose deaths, selective serotonin reuptake inhibitors, sweating
- MeSH terms
- Reboxetine, Antidepressive Agents, Depressive Disorder, Humans, Morpholines, Norepinephrine, Selective Serotonin Reuptake Inhibitors, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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