Clinical Aspects of Fatty Liver Disease
Abstract
The global emergence of obesity as an epidemic has made fatty liver disease a public health problem in the Western world. The increased incidence of obesity has been paralleled by an increase in metabolic syndrome in the same cohort of patients. The net consequence of insulin resistance in a large majority of these obese individuals is hepatic steatosis, which over time in a proportion of these patients progresses to steatohepatitis and cirrhosis. Despite the increased awareness among physicians regarding its presence, the diagnostic process has been hampered by the lack of sensitive and specific population-based screening tests. Liver biopsy remains the gold standard for diagnosis as well as for grading and staging of the disease process but its precise role in the diagnostic conundrum continues to be debated. KEYWORDS Nonalcoholic fatty liver disease - steatohepatitis - insulin resistance - obesity - alanine aminotransferase - aspartate aminotransferase - metabolic syndrome - cirrhosis - gastric bypass - hepatitis C
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Insulin resistance and the metabolic syndrome are associated with several other conditions, including fatty liver, polycystic ovary syndrome, cholesterol gallstones, sleep apnea, lipodystrophies, and protease-inhibitor therapy for HIV.
“Finally, insulin resistance and the metabolic syndrome are associated with a variety of other conditions [75][76][77] ; some of these are fatty liver, 30,78 polycystic ovary syndrome, 79 cholesterol gallstones, 80 sleep apnea, 81 lipodystrophies, 82 and protease-inhibitor therapy for HIV.83”
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- Authors
- Choudhury, J., & Sanyal, A. J.
- Affiliations
- Virginia Commonwealth University (US)
- ORCID
- Sanyal, Arun J
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2004-11
- Volume
- 24
- Issue
- 04
- Pages
- 349-362
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W1999708961
- Cited by
- 82
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 5.27
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Seminars in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK002755, T-32 DK007150-27, T32DK007150, K24 DK02755-04)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- non-alcoholic fatty liver disease, hepatic steatosis, steatohepatitis, liver cirrhosis, obesity, metabolic syndrome, insulin resistance, liver biopsy, alanine aminotransferase, aspartate aminotransferase, gastric bypass, hepatitis C
- MeSH terms
- Acyclovir, Fatty Liver, Hepatitis C, Humans, Insulin Resistance, Liver, Liver Function Tests, Ultrasonography, Comorbidity, Incidence, Prevalence, Disease Progression, Iron Overload
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