Testosterone and obesity

Kelly, D. M.; Jones, T. H.

doi:10.1111/obr.12282

Cited by 487Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Testosterone and obesity

Kelly, D. M., Jones, T. H.·2015·Obesity Reviews

DOI 10.1111/obr.12282

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Abstract

Summary: Testosterone is a key hormone in the pathology of metabolic diseases such as obesity. Low testosterone levels are associated with increased fat mass (particularly central adiposity) and reduced lean mass in males. These morphological features are linked to metabolic dysfunction, and testosterone deficiency is associated with energy imbalance, impaired glucose control, reduced insulin sensitivity and dyslipidaemia. A bidirectional relationship between testosterone and obesity underpins this association indicated by the hypogonadal–obesity cycle and evidence weight loss can lead to increased testosterone levels. Androgenic effects on enzymatic pathways of fatty acid metabolism, glucose control and energy utilization are apparent and often tissue specific with differential effects noted in different regional fat depots, muscle and liver to potentially explain the mechanisms of testosterone action. Testosterone replacement therapy demonstrates beneficial effects on measures of obesity that are partially explained by both direct metabolic actions on adipose and muscle and also potentially by increasing motivation, vigour and energy allowing obese individuals to engage in more active lifestyles. The degree of these beneficial effects may be dependent on the treatment modality with longer term administration often achieving greater improvements. Testosterone replacement may therefore potentially be an effective adjunctive treatment for weight management in obese men with concomitant hypogonadism.

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Multiple groups have observed a significant negative association between obesity and testosterone levels.
“A significant negative association has also been observed between obesity and T levels by multiple groups,72-74 emphasizing the metabolic importance of maintaining T production with age.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [72]

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Authors: Kelly, D. M., & Jones, T. H.
Affiliations: University of Sheffield (GB)
Barnsley Hospital NHS Foundation Trust (GB)
Corresponding author: Kelly, D. M.
ORCID: Kelly, D. M.
Venue: Obesity Reviews
Publisher: Wiley
Published: 2015-05-15
Volume: 16
Issue: 7
Pages: 581-606
ISSN: 1467-7881 (ISSN-L)
1467-789X
DOI: 10.1111/obr.12282
OpenAlex: W1917696566
Semantic Scholar: 2ba7d7b4f771a0393459fb8e8232d26d7dc022cf
Cited by: 487
References: 339
Citations by year: 2026: 43 · 2025: 62 · 2024: 61 · 2023: 54 · 2022: 62 · 2021: 43 · 2020: 45 · 2019: 32 · 2018: 33 · 2017: 31 · 2016: 13 · 2015: 6
FWCI: 4.16
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Obesity Reviews (publishedVersion)
PubMed (publishedVersion)
SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University) (submittedVersion)
Funders: Bayer HealthCare
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: testosterone, obesity, hypogonadism, testosterone replacement therapy, abdominal obesity, fat mass, lean body mass, insulin sensitivity, glycemic control, dyslipidemia, energy balance, weight management
MeSH terms: Adipose Tissue, Adult, Humans, Hypogonadism, Male, Obesity, Receptors, Androgen, Risk Factors, Testosterone, Hormone Replacement Therapy

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