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Cartilage MRI T2 Relaxation Time Mapping: Overview and Applications
Abstract
The sensitivity of magnetic resonance imaging to biochemical and biophysical changes in the extracellular matrix of articular cartilage give it the potential to noninvasively detect the earliest changes of cartilage damage. The transverse relaxation time (T2) of cartilage has been shown to be a sensitive parameter for evaluation of early degeneration in articular cartilage, particularly changes in water and collagen content and tissue anisotropy. Although initial application has been in microimaging of small cartilage explants, in vivo techniques have been developed for cartilage T2 mapping of human joints. In addition to potential application in development of new pharmaceuticals and surgical techniques for preserving cartilage, in vivo cartilage T2 mapping can improve understanding of arthritis, cartilage aging, and response of cartilage to exercise.
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Citations
Cited by
In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
Li, X., Benjamin Ma, C., Link, T. M., Castillo, D.-D., Blumenkrantz, G., Lozano, J., Carballido-Gamio, J., Ries, M., & Majumdar, S. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.01.011 · Cited by 485
Advances in Imaging of Osteoarthritis and Cartilage
Roemer, F. W., Crema, M. D., Trattnig, S., & Guermazi, A. (2011) · Radiology · doi:10.1148/radiol.11101359 · Cited by 220
Liebl, H., Joseph, G., Nevitt, M. C., Singh, N., Heilmeier, U., Subburaj, K., Jungmann, P. M., McCulloch, C. E., Lynch, J. A., Lane, N. E., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204157 · Cited by 149
Wirth, W., Maschek, S., Roemer, F. W., & Eckstein, F. (2016) · Scientific Reports · doi:10.1038/srep34202 · Cited by 23
Metadata
- Authors
- Mosher, T. J., & Dardzinski, B. J.
- Venue
- Seminars in Musculoskeletal Radiology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2004-11
- Volume
- 08
- Issue
- 04
- Pages
- 355-368
- ISSN
- 0189-7860 (ISSN-L)
- 1089-7860
- 1098-898X
- OpenAlex
- W2063423216
- Cited by
- 605
- References
- 0
- FWCI
- 5.70
- Type
- journal article
- Language
- de
- Open access
- closed
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- Mosher, T. J., & Dardzinski, B. J. (2004). Cartilage MRI T2 Relaxation Time Mapping: Overview and Applications. Seminars in Musculoskeletal Radiology. https://doi.org/10.1055/s-2004-861764
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