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Cited by 123TGF-β signaling in diseasesSkin Protection and AgingCollagen: Extraction and Characterization

The DOI matches its Crossref record.

Asiaticoside Induces Human Collagen I Synthesis through TGFβ Receptor I Kinase (TβRI Kinase)-Independent Smad Signaling

Lee, Jongsung, Jung, Eunsun, Kim, Youngji, Park, Junho, Park, Jinil, Hong, Sungtaek, Kim, Jieun, Hyun, Changgu, Kim, Yeong Shik, Park, Deokhoon·2006·Planta Medica
DOI 10.1055/s-2005-916227
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Abstract

Skin aging appears to be principally related to a decrease in the levels of type I collagen, the primary component of the skin dermis. Asiaticoside, a saponin component isolated from Centella asiatica, has been shown to induce type I collagen synthesis in human dermal fibroblast cells. However, the mechanism underlying asiaticoside-induced type I collagen synthesis, especially at a molecular level, remains only partially understood. In this study, we have attempted to characterize the action mechanism of asiaticoside in type I collagen synthesis. Asiaticoside was determined to induce the phosphorylation of both Smad 2 and Smad 3. In addition, we detected the asiaticoside-induced binding of Smad 3 and Smad 4. In a consistent result, the nuclear translocation of the Smad 3 and Smad 4 complex was induced via treatment with asiaticoside, pointing to the involvement of asiaticoside in Smad signaling. In addition, SB431542, an inhibitor of the TGFbeta receptor I (TbetaRI) kinase, which is known to be an activator of the Smad pathway, was not found to inhibit both Smad 2 phosphorylation and Type 1 collagen synthesis induced by asiaticoside. Therefore, our results show that asiaticoside can induce type I collagen synthesis via the activation of the TbetaRI kinase-independent Smad pathway.

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Metadata

Authors
Lee, J., Jung, E., Kim, Y., Park, J., Park, J., Hong, S., Kim, J., Hyun, C., Kim, Y. S., & Park, D.
Affiliations
Seoul National University (KR)
ORCID
Venue
Planta Medica
Publisher
Georg Thieme Verlag KG
Published
2006-01
Volume
72
Issue
4
Pages
324-328
ISSN
  • 0032-0943 (ISSN-L)
  • 1439-0221
DOI
10.1055/s-2005-916227
OpenAlex
W1983420953
Cited by
123
References
0
Citations by year
2026: 9 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 6
FWCI
2.16
Type
journal article
Language
de
Open access
closed
Locations
  • Planta Medica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Keywords
asiaticoside, Centella asiatica, type I collagen synthesis, Smad signaling, Smad2 phosphorylation, Smad3 phosphorylation, SMAD4, skin aging, dermal fibroblasts, saponins, nuclear translocation
MeSH terms
Receptor, Transforming Growth Factor-beta Type I, Fibroblasts, Humans, Keratolytic Agents, Phytotherapy, Plant Extracts, Triterpenes, Blotting, Western, Signal Transduction, Skin Aging, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Collagen Type I, Centella, Smad3 Protein, Smad4 Protein

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