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Asiaticoside Induces Human Collagen I Synthesis through TGFβ Receptor I Kinase (TβRI Kinase)-Independent Smad Signaling
Abstract
Skin aging appears to be principally related to a decrease in the levels of type I collagen, the primary component of the skin dermis. Asiaticoside, a saponin component isolated from Centella asiatica, has been shown to induce type I collagen synthesis in human dermal fibroblast cells. However, the mechanism underlying asiaticoside-induced type I collagen synthesis, especially at a molecular level, remains only partially understood. In this study, we have attempted to characterize the action mechanism of asiaticoside in type I collagen synthesis. Asiaticoside was determined to induce the phosphorylation of both Smad 2 and Smad 3. In addition, we detected the asiaticoside-induced binding of Smad 3 and Smad 4. In a consistent result, the nuclear translocation of the Smad 3 and Smad 4 complex was induced via treatment with asiaticoside, pointing to the involvement of asiaticoside in Smad signaling. In addition, SB431542, an inhibitor of the TGFbeta receptor I (TbetaRI) kinase, which is known to be an activator of the Smad pathway, was not found to inhibit both Smad 2 phosphorylation and Type 1 collagen synthesis induced by asiaticoside. Therefore, our results show that asiaticoside can induce type I collagen synthesis via the activation of the TbetaRI kinase-independent Smad pathway.
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“Asiaticoside can induce type I collagen synthesis via the activation of the TGF‐β receptor I kinase‐independent Smad signalling.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [98]
In the citing paper
“Instead, asiaticoside and madecassoside prove cosmetically useful by inducing the production of collagen and thus preventing skin‐ageing, which is caused as a result of low Type 1 collagen secretion in the dermis.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [98]
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Metadata
- Authors
- Lee, J., Jung, E., Kim, Y., Park, J., Park, J., Hong, S., Kim, J., Hyun, C., Kim, Y. S., & Park, D.
- Affiliations
- Seoul National University (KR)
- ORCID
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2006-01
- Volume
- 72
- Issue
- 4
- Pages
- 324-328
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1983420953
- Cited by
- 123
- References
- 0
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 2.16
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiaticoside, Centella asiatica, type I collagen synthesis, Smad signaling, Smad2 phosphorylation, Smad3 phosphorylation, SMAD4, skin aging, dermal fibroblasts, saponins, nuclear translocation
- MeSH terms
- Receptor, Transforming Growth Factor-beta Type I, Fibroblasts, Humans, Keratolytic Agents, Phytotherapy, Plant Extracts, Triterpenes, Blotting, Western, Signal Transduction, Skin Aging, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Collagen Type I, Centella, Smad3 Protein, Smad4 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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