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Asiaticoside Induces Human Collagen I Synthesis through TGFβ Receptor I Kinase (TβRI Kinase)-Independent Smad Signaling
Abstract
Skin aging appears to be principally related to a decrease in the levels of type I collagen, the primary component of the skin dermis. Asiaticoside, a saponin component isolated from Centella asiatica, has been shown to induce type I collagen synthesis in human dermal fibroblast cells. However, the mechanism underlying asiaticoside-induced type I collagen synthesis, especially at a molecular level, remains only partially understood. In this study, we have attempted to characterize the action mechanism of asiaticoside in type I collagen synthesis. Asiaticoside was determined to induce the phosphorylation of both Smad 2 and Smad 3. In addition, we detected the asiaticoside-induced binding of Smad 3 and Smad 4. In a consistent result, the nuclear translocation of the Smad 3 and Smad 4 complex was induced via treatment with asiaticoside, pointing to the involvement of asiaticoside in Smad signaling. In addition, SB431542, an inhibitor of the TGFbeta receptor I (TbetaRI) kinase, which is known to be an activator of the Smad pathway, was not found to inhibit both Smad 2 phosphorylation and Type 1 collagen synthesis induced by asiaticoside. Therefore, our results show that asiaticoside can induce type I collagen synthesis via the activation of the TbetaRI kinase-independent Smad pathway.
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“Asiaticoside can induce type I collagen synthesis via the activation of the TGF‐β receptor I kinase‐independent Smad signalling.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [98]
In the citing paper
“Instead, asiaticoside and madecassoside prove cosmetically useful by inducing the production of collagen and thus preventing skin‐ageing, which is caused as a result of low Type 1 collagen secretion in the dermis.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [98]
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Metadata
- Authors
- Lee, J., Jung, E., Kim, Y., Park, J., Park, J., Hong, S., Kim, J., Hyun, C., Kim, Y. S., & Park, D.
- Affiliations
- Seoul National University (KR)
- ORCID
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2006-01
- Volume
- 72
- Issue
- 4
- Pages
- 324-328
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1983420953
- Cited by
- 123
- References
- 0
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 2.16
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiaticoside, Centella asiatica, type I collagen synthesis, Smad signaling, Smad2 phosphorylation, Smad3 phosphorylation, SMAD4, skin aging, dermal fibroblasts, saponins, nuclear translocation
- MeSH terms
- Receptor, Transforming Growth Factor-beta Type I, Fibroblasts, Humans, Keratolytic Agents, Phytotherapy, Plant Extracts, Triterpenes, Blotting, Western, Signal Transduction, Skin Aging, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Collagen Type I, Centella, Smad3 Protein, Smad4 Protein
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