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Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis
Abstract
Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by NADH or NADPH oxidation were also completely inhibited by these diterpenes at the concentration of 3-30 microM. Furthermore, carnosic acid protected red cells against oxidative hemolysis. These phenolic diterpenes were shown to be effective to protect biological systems against oxidative stresses.
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Cited by
Subcritical Water Extraction of Antioxidant Compounds from Rosemary Plants
Ibañez, E., Kubátová, A., Señoráns, F. J., Cavero, S., Reglero, G., & Hawthorne, S. B. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025878j · Cited by 417
Offord, E. A., Gautier, J.-C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00831-6 · Cited by 254
Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata
Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y., & Kinoshita, T. (1998) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(97)10034-7 · Cited by 251
Self-citationCarnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms
Loussouarn, M., Krieger-Liszkay, A., Svilar, L., Bily, A., Birtić, S., & Havaux, M. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.01183 · Cited by 234
Zakaria, S. M., & Kamal, S. M. M. (2016) · Food Engineering Reviews · doi:10.1007/s12393-015-9119-x · Cited by 223
Metadata
- Authors
- Haraguchi, H., Saito, T., Okamura, N., & Yagi, A.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1995-08
- Volume
- 61
- Issue
- 04
- Pages
- 333-336
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2053452745
- Cited by
- 168
- References
- 0
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haraguchi, H., Saito, T., Okamura, N., & Yagi, A. (1995). Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis. Planta Medica. https://doi.org/10.1055/s-2006-958094
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