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Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis

Haraguchi, Hiroyuki, Saito, Takashi, Okamura, Nobuyuki, Yagi, Akira·1995·Planta Medica

Abstract

Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by NADH or NADPH oxidation were also completely inhibited by these diterpenes at the concentration of 3-30 microM. Furthermore, carnosic acid protected red cells against oxidative hemolysis. These phenolic diterpenes were shown to be effective to protect biological systems against oxidative stresses.

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Metadata

Authors
Haraguchi, H., Saito, T., Okamura, N., & Yagi, A.
Venue
Planta Medica
Published
1995-08
Volume
61
Issue
04
Pages
333-336
ISSN
  • 0032-0943 (ISSN-L)
  • 1439-0221
OpenAlex
W2053452745
Cited by
168
References
0
FWCI
2.86
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis. https://app.cochat.ai/papers/10.1055/s-2006-958094
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Haraguchi, H., Saito, T., Okamura, N., & Yagi, A. (1995). Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis. Planta Medica. https://doi.org/10.1055/s-2006-958094

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