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Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis
Abstract
Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.
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“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
In the citing paper
“This favourable effect is observed with a quicker wound contraction, probably owing to the stimulation of fibronectin [69] and collagen I synthesis [21,31] and matrix remodelling [31].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
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“…(1), one of the major triterpenoid acids present in the herb Centella asiatica , has been reported to possess many pharmacological properties, including wound healing (Bonte et al. 1994), antioxidant (Yin et al. 2012), anti-inflammatory (Won et al. 2010) and antidiabetic activity (Hsu et al. 2015).”
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Centella asiatica in Dermatology
Harlim, A. (2018)
Pemanfaatan Gel Centella Asiatica/Daun Pegagan untuk Membantu Memudarkan Stretch Mark pada Ibu Nifas
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Pharmacognostic Survey on Paeonia Broteri – An Iberian Endemism
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BackgroundDevelopment of Hydrogel Sun Patch with Wound Healing Efficacy
Nam, D., Woo, J., Kim, Y., et al. (2025) · Journal of Wound Management and Research · doi:10.22467/jwmr.2024.03118
“병풀은 오래 전부터 피부 창상 등 의 치료에 이용되어 왔으며 아토피성 피부염에 적용할 경우 가려움증 완화 및 손상된 피부 회복에도 효과가 있다고 밝혀졌다 [19,20].”
Rosa damascena extract is as effectıve as Centella asiatica in wound healing
Yildiz, M. N., Tüzün, A., Bilge, H., YİLDİZHAN, E., & Çetin, A. (2025) · Revista Científica de la Facultad de Ciencias Veterinarias · doi:10.52973/rcfcv-e361759
Potential of herbal remedies in treatment of wounds and scars
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Suntivich, R., Malaphong, C., Chaiyen, P., Leartsakulpanich, U., & Maenpuen, S. (2026) · ACS Omega · doi:10.1021/acsomega.6c04697
Metadata
- Authors
- Bonte, F., Dumas, M., Chaudagne, C., & Meybeck, A.
- Affiliations
- LVMH (France) (FR)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-04
- Volume
- 60
- Issue
- 02
- Pages
- 133-135
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1996838400
- Cited by
- 166
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiatic acid, madecassic acid, asiaticoside, ursane triterpenoids, collagen I synthesis, human dermal fibroblasts, vitamin C, sugar moiety
- MeSH terms
- Adult, Carbohydrate Sequence, Cells, Cultured, Collagen, Humans, Molecular Sequence Data, Terpenes, Triterpenes, Pentacyclic Triterpenes
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