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Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis
Abstract
Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.
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“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
In the citing paper
“This favourable effect is observed with a quicker wound contraction, probably owing to the stimulation of fibronectin [69] and collagen I synthesis [21,31] and matrix remodelling [31].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
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Triterpene Composition and Bioactivities of Centella asiatica
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“This tropical plant has been reported to have been used for various medicinal purposes such as for wound healing [3-5], treatment of asthma, ulcers, lepsory, lupus, vein diseases [1,6], memory improvement [7,8], as an antidepressant [9], antibacterial, antifungal [10], psoriasis [11] and anti-cancer agent [12] even th…”
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Lacaille‐Dubois, M., & Wagner, H. (1996) · Phytomedicine · doi:10.1016/s0944-7113(96)80081-x · Cited by 245
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“Asiatic acid has also been found to increase collagen synthesis, which is important in the healing process [12,25].”
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Arribas-López, E., Zand, N., Ojo, O., Snowden, M. J., & Kochhar, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063266 · Cited by 143
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“…constituents that possess this variety of pharmacological activities, including stimulation of fibroblast proliferation and collagen synthesis (Bonte et al., 1994; Maquart et al., 1990; Lu et al., 2004), anti-inflammatory (Yun et al., 2008; Won et al., 2010), antiulcer (Cheng et al., 2004),…”
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“Wound-healing mechanisms may be contributed to stimulate the production of antioxidants in wound site and to provide a favourable environment for tissue healing (Shukla, Rasik, & Dhawan, 1999 ); wound-healing effects may be due to the up-regulation of human collagen I expression (Bonte, Dumas, Chadgne, & Meybeck, 1993…”
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Role of Ficus deltoidea extract in the enhancement of wound healing in experimental rats
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Acute toxicity study and wound healing potential of Gynura procumbens leaf extract in rats
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“Asiaticoside was previously reported to promote type I collagen production in human dermal fibroblasts (Bonte et al., 1994; Lee et al., 2006; Lu et al., 2004a; Lu et al., 2004b).”
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Anti-glycative effects of asiatic acid in human keratinocyte cells
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“[17] indicated this triterpene stimulating synthesis of Type I collagen.”
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Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma
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“asiatica, and promotion of the metabolic pathway in fibroblasts is still under discussion.([14]) Preparation of pure standards of triterpenoids is significant for further scientific studies of these compounds.”
BackgroundKuo, C.-W., Chiu, Y.-F., Wu, M., Li, M.-H., Wu, C.-N., Chen, W.-S., & Huang, C.-H. (2021) · Polymers · doi:10.3390/polym13040579 · Cited by 39
“The mixture of these components stimulates collagen synthesis by human fibroblasts [14].”
Plengmuankhae, W., & Tantitadapitak, C. (2015) · South African Journal of Botany · doi:10.1016/j.sajb.2015.01.013 · Cited by 39
Wound Healing Activities of Rafflesia Hasseltii Extract in Rats
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“Wound healing effects may be due to up-regulation of human collagen I expression [9] and an increase in tensile strength of the wounds [10].”
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“Wound healing effects may be due to regulation of collagen expression (Bonte et al., 1993) and increase in tensile strength of the wounds (Suguna et al.”
BackgroundAsiatic acid attenuates high-fat diet-induced impaired spermatogenesis
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“Asiatic acid (AA), which is a pentacyclic triterpene isolated from Centella asiatica , has been demonstrated to possess a number of pharmacological activities (18).”
Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation
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“Madecasic acid and asiaticoside, ingredients for wound healing ointment derived from Centella asiatica, have become global raw materials applied in wrinkle-improving cosmetics [26,27].”
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“Asiaticoside has been known for its effect on wound healing (6–8) by stimulation of extracellular matrix accumulation (9) and collagen synthesis (10, 11).”
BackgroundNew Triterpenoid Glycosides fromCentella asiatica
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“duced damage and is able to promote wound healing (50).”
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“It also has the potential to inhibit osteoporosis [18,19] and fibrotic diseases [13,20,21], and to induce collagen synthesis and wound healing [22].”
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“Asiaticoside helps in collagen I synthesis in human clinically used as a wound healing agent in combination with madecassic and asiatic ascids [15].”
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Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation.
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“Additionally, Asiatic acid and madecassic acid have shown an increase in peptidic hydroxyproline indicating enhanced collagen production remodeling in wounds [14,15].”
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Scar Management Practice and Science
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“As the scar matures, the ratio of type III to type I returns to normal levels.(21,22) Thus, any agent that encourages type I collagen formation and returns to stable ratios is advantageous to scar outcome.”
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Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract
Karsono, A. H., Tandrasasmita, O. M., Berlian, G., & Tjandrawinata, R. R. (2021) · Journal of Experimental Pharmacology · doi:10.2147/jep.s299547 · Cited by 18
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Effect of Asiaticoside on 99mTc-Tetrofosmin and 99mTc-Sestamibi Uptake in MCF-7 Cells
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“Many studies have reported a positive correlation between the administration of asiaticoside and antitumor activity (30), inhibition of DNA synthesis (33), therapeutic interventions for many human cancer types (34,35), and protection of the liver from damage.”
BackgroundThe Identification of New Triterpenoids in Eucalyptus globulus Wood
Lourenço, A., Marques, A. V., & Gominho, J. (2021) · Molecules · doi:10.3390/molecules26123495 · Cited by 15
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Metadata
- Authors
- Bonte, F., Dumas, M., Chaudagne, C., & Meybeck, A.
- Affiliations
- LVMH (France) (FR)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-04
- Volume
- 60
- Issue
- 02
- Pages
- 133-135
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1996838400
- Cited by
- 166
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiatic acid, madecassic acid, asiaticoside, ursane triterpenoids, collagen I synthesis, human dermal fibroblasts, vitamin C, sugar moiety
- MeSH terms
- Adult, Carbohydrate Sequence, Cells, Cultured, Collagen, Humans, Molecular Sequence Data, Terpenes, Triterpenes, Pentacyclic Triterpenes
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