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Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis
Abstract
Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.
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“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
In the citing paper
“This favourable effect is observed with a quicker wound contraction, probably owing to the stimulation of fibronectin [69] and collagen I synthesis [21,31] and matrix remodelling [31].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
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Triterpene Composition and Bioactivities of Centella asiatica
Hashim, P., Sidek, H., Helan, M. H. M., Sabery, A., Palanisamy, U. D., & Ilham, M. (2011) · Molecules · doi:10.3390/molecules16021310 · Cited by 266
“This tropical plant has been reported to have been used for various medicinal purposes such as for wound healing [3-5], treatment of asthma, ulcers, lepsory, lupus, vein diseases [1,6], memory improvement [7,8], as an antidepressant [9], antibacterial, antifungal [10], psoriasis [11] and anti-cancer agent [12] even th…”
BackgroundResultA review of the biological and pharmacological activities of saponins
Lacaille‐Dubois, M., & Wagner, H. (1996) · Phytomedicine · doi:10.1016/s0944-7113(96)80081-x · Cited by 245
Somboonwong, J., Kankaisre, M., Tantisira, B., & Tantisira, M. H. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-103 · Cited by 232
“Asiatic acid has also been found to increase collagen synthesis, which is important in the healing process [12,25].”
BackgroundCentella asiatica in Dermatology: An Overview
Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., Dańczak‐Pazdrowska, A., & Brzezińska, M. (2014) · Phytotherapy Research · doi:10.1002/ptr.5110 · Cited by 231
“…increases the collagen synthesis, decreases the activity of metalloproteinases and thus increases the collagen deposition (Tenni et al., 1988; Maquart et al., 1990; Bonté et al., 1994; Bonté et al., 1995; Lu et al., 2004a, 2004b; Hashim et al., 2011; Tang et al., 2011; Nowwarote et al., 2013).”
BackgroundYazarlu, O., Iranshahi, M., Kashani, H. R. K., Reshadat, S., Habtemariam, S., Iranshahy, M., & Hasanpour, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105841 · Cited by 230
Metadata
- Authors
- Bonte, F., Dumas, M., Chaudagne, C., & Meybeck, A.
- Affiliations
- LVMH (France) (FR)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-04
- Volume
- 60
- Issue
- 02
- Pages
- 133-135
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1996838400
- Cited by
- 166
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiatic acid, madecassic acid, asiaticoside, ursane triterpenoids, collagen I synthesis, human dermal fibroblasts, vitamin C, sugar moiety
- MeSH terms
- Adult, Carbohydrate Sequence, Cells, Cultured, Collagen, Humans, Molecular Sequence Data, Terpenes, Triterpenes, Pentacyclic Triterpenes
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