Alpha-Glycerylphosphorylcholine Administration Increases the GH Responses to GHRH of Young and Elderly Subjects
Abstract
Growth hormone (GH) secretion is decreased during aging in humans and in rodents. This decrease may be due to increased hypothalamic somatostatin release, which is inhibited by cholinergic agonists, or to decreased secretion of GHRH. Alpha-glyceryl-phosphorylcholine (alpha-GFC) is a putative acetylcholine precursor used in the treatment of cognitive disorders in the elderly. In order to learn what effect alpha-GFC had on GH secretion, GH-release hormone (GHRH) was given to young and old human volunteers, with or without the addition of alpha-GFC. GH secretion was greater in the younger subjects than in the old individuals, and both groups had a greater GH response to the GHRH+alpha-GFC than to GHRH alone. The potentiating effect of alpha-GFC on GH secretion was more pronounced in the elderly subjects. These findings confirm the observation that aged individuals respond less well to GHRH than younger subjects, and provides further evidence that increased cholinergic tone enhances GH release.
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Circulating growth hormone levels have been shown in previous studies to increase with A-GPC supplementation [2,14,35].
“Circulating growth hormone levels were also evaluated after A-GPC supplementation, as it has been shown in previous studies to increase growth hormone levels [2,14,35].”
From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [35]
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Parnetti, L., Mignini, F., Tomassoni, D., Traini, E., & Amenta, F. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.043 · Cited by 122 · see citing works
Traini, E., Bramanti, V., & Amenta, F. (2013) · Current Alzheimer Research · doi:10.2174/15672050113106660173 · Cited by 78 · see citing works
The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength
Bellar, D., LeBlanc, N. R., & Campbell, B. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0103-x · Cited by 43 · see citing works
Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men
Kerksick, C. M. (2024) · Nutrients · doi:10.3390/nu16234240 · Cited by 5 · see citing works
“Circulating growth hormone levels were also evaluated after A-GPC supplementation, as it has been shown in previous studies to increase growth hormone levels [2,14,35].”
- Authors
- Ceda, G., Ceresini, G., Denti, L., Marzani, G., Piovani, E., Banchini, A., Tarditi, E., & Valenti, G.
- Affiliations
- University of Parma (IT)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1992-03
- Volume
- 24
- Issue
- 03
- Pages
- 119-121
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2014204573
- Cited by
- 27
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- growth hormone secretion, growth hormone-releasing hormone, aging, cholinergic tone, acetylcholine precursor, somatostatin, hypothalamic regulation, elderly subjects
- MeSH terms
- Adult, Age Factors, Female, Glycerylphosphorylcholine, Humans, Male, Middle Aged, Parasympathetic Nervous System, Growth Hormone, Growth Hormone-Releasing Hormone
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