Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent.
Abstract
Cholinergic precursors have represented the first approach to counter cognitive impairment occurring in adultonset dementia disorders. These compounds were early leaved because their clinical efficacy was not clearly demonstrated. This is probably not true for some choline-containing phospholipids including choline alphoscerate. Choline alphoscerate increases the release of acetylcholine in rat hippocampus, facilitates learning and memory in experimental animals, improves brain transduction mechanisms and decreases age-dependent structural changes occurring in rat brain areas involved in learning and memory. The compound exerts neuroprotective effects in models of altered cholinergic neurotransmission and of brain vascular injury. In clinical studies choline alphoscerate improved memory and attention impairment, as well as affective and somatic symptoms in dementia disorders. An ongoing trial indicates that association between the acetylcholinesterase inhibitor donepezil and choline alphoscerate is accompanied by an improvement in several cognitive tests superior to that induced by donepezil alone. It is suggested that this association may represent a therapeutic option to prolong beneficial effects of cholinergic therapies in Alzheimer's disease patients with concomitant ischemic cerebrovascular disorders. In summary, choline alphoscerate has significant effects on cognitive function with a good safety profile and tolerability. Although limited both in terms of size of the samples investigated and of the length of treatment, preclinical and clinical results presented suggest that cognitive enhancing capabilities of choline alphoscerate merit of being further investigated in appropriate trials.
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α-GPC is converted to free choline through hydrolysis in the gut mucosa.
“This outcome may be relevant as α-GPC is converted to free choline through hydrolysis in the gut mucosa,7 and increased plasma levels of choline reflect the absorption of α-GPC.24”
From Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years (2021) · cites this paper as [7]
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Choline supplements: An update
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Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years
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- Authors
- Traini, E., Bramanti, V., & Amenta, F.
- Affiliations
- Università di Camerino (IT)
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2013-12-31
- Volume
- 10
- Issue
- 10
- Pages
- 1070-1079
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W2143355662
- Cited by
- 78
- References
- 63
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 14 · 2023: 13 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- Unicam Scientific Publications (University of Camerino) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- choline alphoscerate, choline phospholipids, cognitive enhancement, dementia, Alzheimer's disease, acetylcholine release, hippocampus, learning and memory, neuroprotection, acetylcholinesterase inhibitors, ischemic cerebrovascular disease
- MeSH terms
- Animals, Brain, Cognition, Cognition Disorders, Glycerylphosphorylcholine, Humans, Phospholipids
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