3,5-T2Stimulates Oxygen Consumption, But Not Glucose Uptake in Human Mononuclear Blood Cells
Abstract
L-thyroxine (T4), L-triiodothyronine (T3) and 3,5-di-iodothyronine (T2) rapidly (within 30 min) stimulated oxygen consumption in human mononuclear blood cells, whereas the D isomers of T4 and T3 and Triac had no stimulatory effect. Oxygen consumption was stimulated by the same magnitude by equimolar concentrations (5-500 nmol/l) of L-T4, L-T3 and 3,5-T2 reaching a plateau at 100 nmol/l of 0.025 umol/mg DNA x h. The stimulatory effects of T4 and T3, but not of T2 were inhibited by PTU. Glucose uptake was stimulated only by L-T4 and L-T3, whereas 3,5-T2, Triac and the D-isomers of T4 and T3 had no effect. The dose response curve reached an apparent maximum at 100 nmol/l of 0.30 mmol/l x mg DNA x h and PTU had no effect on iodothyronine stimulated glucose uptake. We conclude that 3,5-T2 is a significant intracellular stimulator of oxygen consumption, whereas T3 and T4 stimulate glucose uptake.
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3,5-T2 increases the rate of oxygen consumption in perfused rat liver, blood mononuclear cells, and rat liver mitochondria.
“Compound 3,5-T2 by itself increases the rate of oxygen consumption in perfused rat liver (Horst et al. 1989), blood mononuclear cells (Kvetny 1992), and rat liver mitochondria (Lanni et al. 1992, 1993, O'Reilly & Murphy 1992)”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Kvetny 1992
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Kvetny, J., Heldgaard, P. E., Bladbjerg, E. M., & Gram, J. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02088.x · Cited by 280 · see citing works
Self-citationMetabolic Effects of Thyroid Hormone Derivatives
Moreno, M., de Lange, P., Lombardi, A., Silvestri, E., Lanni, A., & Goglia, F. (2008) · Thyroid · doi:10.1089/thy.2007.0248 · Cited by 226 · see citing works
Padron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69 · see citing works
Dietrich, J. W., Müller, P., Schiedat, F., Schlömicher, M., Strauch, J., Chatzitomaris, A., Klein, H. H., Mügge, A., Köhrle, J., Rijntjes, E., et al. (2015) · European Thyroid Journal · doi:10.1159/000381543 · Cited by 68 · see citing works
Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function
van der Spek, A. H., Surovtseva, O. V., Jim, K. K., van Oudenaren, A., Brouwer, M. C., Vandenbroucke-Grauls, C. M. J. E., Leenen, P. J. M., van de Beek, D., Hernandez, A., Fliers, E., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00053 · Cited by 62 · see citing works
- Authors
- Kvetny, J.
- Affiliations
- Odense University Hospital (DK)
- Corresponding author
- Kvetny, J.
- ORCID
- Kvetny, J.
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1992-07
- Volume
- 24
- Issue
- 07
- Pages
- 322-325
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W1994723069
- Cited by
- 40
- References
- 0
- Citations by year
- 2021: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2012: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- 3,5-diiodothyronine, triiodothyronine, thyroxine, oxygen consumption, glucose uptake, thyroid hormone stimulation, D-isomer
- MeSH terms
- Adult, Blood Glucose, Diiodothyronines, DNA, Humans, Middle Aged, Neutrophils, Oxygen Consumption, Thyroxine, Triiodothyronine, In Vitro Techniques
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