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The Effect of Trimipramine on Sleep in Patients with Major Depressive Disorder
Open accessAbstract
Antidepressants generally inhibit REM sleep. This effect is often considered to be a crucial feature of these drugs. Trimipramine, however, is a tricyclic antidepressant which does not inhibit REM sleep in rats (Khazan and Brown, 1970; Wassennan and Khazan, 1971). This result could be confirmed in man: Dunleavy et al. (1972) administered this drug to two healthy volunteers and found no alteration of REM sleep. In our present study we examined the action of trimipramine on sleep in patients with major depressive disorder. We were especially interested in the effect on REM sleep parameters. In order to elucidate the mode of action of this 'drug, we investigated, in addition, the question of whether the effect of trimipramine on prolactin, human growth hormone, and cortisol resembled that of other antidepressants.
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TCAs, with the exception of trimipramine, suppress REM sleep, with clomipramine exerting the most potent effect in standard antidepressant dosage.
“With the exception of trimipramine [Ware et al., 1989;Wiegand et al., 1986], all of the TCAs examined suppress REM sleep, with clomipramine exerting the most potent effect in standard antidepressant dosage [Thase and Kupfer, 1987].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Wiegand et al., 1986
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Research works printed but not linked: 1
- Kales, A., M. B. Scharf, J. D. Kales, E. O. Bixler, M. Djoko: Sleep laboratory drug evaluation: thioridazine (mellaril), a REM enhancing drug. In: Sleep research, ed. by M. H. Chase, W. C. Stern, P. L. Walter. Brain Information Service/Brain Research Institute, University of California, Los Angeles 1974, Vol. 3, 55
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Metadata
- Authors
- Wiegand, M., Berger, M., Zulley, J., & von Zerssen, D.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 1986-07
- Volume
- 19
- Issue
- 04
- Pages
- 198-199
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2006973262
- Cited by
- 59
- References
- 0
- Citations by year
- 2017: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Pharmacopsychiatry (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- trimipramine, REM sleep, major depressive disorder, tricyclic antidepressants, sleep parameters, prolactin, human growth hormone, cortisol, antidepressant side effects
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