The DOI matches its Crossref record.
Serotonergic Agonists and Antagonists Affect Endurance Performance in the Rat
Abstract
The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p < 0.05) in a dose related manner by increasing dosages of quipazine dimaleate (QD: general 5-HT agonist) (0-5 mg.kg-1 i.p.) administered immediately prior to exercise (treadmill running at 20 m.min-1 and 5% grade). Conversely, RUN-EXH was increased (p < 0.05) by the greatest dosage of LY 53,857 (LY: 5-HT1C and 5-HT2 antagonist) (1.5 mg.kg-1 i.p.). Drug effects were similar in male and female rats. The negative effects of QD administration on RUN-EXH were not attenuated by administration of the peripherally restricted antagonist, xylamidine tosylate (up to 200 ug.kg-1 i.p.). The results of this investigation indicated that fatigue during prolonged exercise can be influenced by direct pharmacological administration of a serotonergic agonist and antagonist and that the mechanisms underlying these effects are likely to be central (brain) in nature.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fatigue can set in during exercise when dopamine levels start to drop while serotonin levels are still elevated [98].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [98]
Citations
Cited by
Sorted by citations
Items 101–115 of 115
Mécanismes biologiques du syndrome de surentraînement
Serrurier, B., & Guezennec, C. Y. (1997) · Revue Française des Laboratoires · doi:10.1016/s0338-9898(97)80210-7
The Effect of Manipulating the IL-6 Response to Exercise on Biomarkers and Exercise Performance
Walshe, I. H. (2012) · Northumbria Research Link (Northumbria University)
endurance exercise performance Effects of l-tyrosine and carbohydrate ingestion on
Parcell, A. C., Sawyer, R. D., Conlee, R. K., Nicholas, C., Cermak, N. M., Yamamoto, T., MEEUSEN, R. R., Burke, L. M., Stear, S. J., & Castell, L. M. (2015)
Portero, P., & Gomez-Mérino, D. (2012) · EMC - Kinésithérapie - Médecine physique - Réadaptation · doi:10.1016/s1283-0887(12)56632-6
Singh, A. M. (2016) · UWSpace (University of Waterloo)
Hadjicharalambous, M. (2004) · Enlighten: Theses (The University of Glasgow)
Deception and Exercise Performance During Repeated 4-km Cycling Time Trials
Shei, R., Chapman, R. F., Raglin, J. S., et al. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000494857.07135.99
Al-Sinbil, S. N. T., Al-Mahdawi, Z. M. M., & Noaman, H. E. (2017) · doi:10.24897/acn.64.68.48
“The increasing of release of dopamine and decreasing the catabolism of dopamine as long as the exercise persist (Bailey et al. 1993), so increase of dopamine in L-carnitine received group after exercise was in addition to physical activity , L-carnitine act by enchancing glutatione level which…”
BackgroundStanton, D. A. (2021) · doi:10.33915/etd.10195 · Cited by 1
Laure, P., & Dine, G. (2018) · Elsevier eBooks · doi:10.1016/b978-2-294-76041-9.00006-4
The Physiological and Perceptual Responses to Concurrent Training in Soccer Players
Sparkes, W. (2022) · Cronfa (Swansea University) · doi:10.23889/suthesis.60294
Effects of transcranial pulsed electrical stimulation on fatigue rats
Jin, F., Shen, L., Li, H., et al. (2022) · International Conference on Biomedical and Intelligent Systems (IC-BIS) · doi:10.1117/12.2659681
Excessive training alters hippocampal tyrosine hydroxylase and dopamine homeostasis in mice
da Rocha, A. L., Floriano, J. P., Pinto, A. P., Cintra, D. E., Ropelle, E. R., de Freitas, E. C., Pauli, J. R., & da Silva, A. S. R. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.08.006
Metadata
- Authors
- Bailey, S., Davis, J., & Ahlborn, E.
- Affiliations
- University of South Carolina (US)
- ORCID
- Davis, J.
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1993-08
- Volume
- 14
- Issue
- 06
- Pages
- 330-333
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2002111073
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonergic agonists, serotonergic antagonists, endurance performance, xylazine, prolonged exercise, sex differences, central nervous system mechanisms
- MeSH terms
- Amidines, Animals, Dose-Response Relationship, Drug, Ergolines, Female, Injections, Intraperitoneal, Male, Physical Endurance, Placebos, Quipazine, Running, Serotonin Antagonists, Time Factors, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
