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In vitro Acetylcholinesterase Inhibitory Activity of the Essential Oil from Acorus calamus and its Main Constituents
Abstract
The in vitro acetylcholinesterase (AChE) inhibitory potential of the hydroalcoholic extract and of the essential oil from Acorus calamus (AC) rhizomes and that of its major constituents were evaluated based on the Ellman's method. GC/MS analysis of the oil revealed that the major constituents were beta-asarone (79.54%) and alpha-asarone (8.47%). The IC50 values were obtained for the hydroalcoholic extract, the essential oil, beta-asarone and alpha-asarone and were 182.31+/-16.78 microg/mL, 10.67+/-0.81 microg/mL, 3.33+/-0.02 microM and 46.38+/-2.69 microM, respectively. Physostigmine was used as standard inhibitor with an IC50 value of 0.28+/-0.015 microM. The experimental observations revealed that the AC essential oil and its constituents have significant AChE inhibitory potential. beta-Asarone, the major phytoconstituent present in the essential oil, showed the maximum inhibitory potential.
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“The β-asarone showed the maximum inhibition against AChE [95].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [95]
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Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity
Mukherjee, P. K., Venkatesan, K., & Houghton, P. J. (2007) · Phytotherapy Research · doi:10.1002/ptr.2224 · Cited by 228
“AChE activity was measured using a 96-well microplate reader (Ren et al., 2006; Mukherjee et al., 2007b) based on Ellman’s method (Ellman et al., 1961).”
BackgroundMethodSelf-citationTherapeutic and pharmacological efficacy of selective Indian medicinal plants – A review
Prasathkumar, M., Anisha, S., Chenthamara, D., et al. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100029 · Cited by 227
Rajput, S. B., Tonge, M. B., & Karuppayil, S. M. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.09.020 · Cited by 205
Metadata
- Authors
- Mukherjee, P., Kumar, V., Mal, M., & Houghton, P.
- Affiliations
- Jadavpur University (IN)
- King's College London (GB)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2007-03
- Volume
- 73
- Issue
- 3
- Pages
- 283-285
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2086672378
- Cited by
- 136
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 11
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- acetylcholinesterase inhibition, Acorus calamus, essential oils, β-asarone, α-asarone, hydroalcoholic extract, rhizome, IC50, physostigmine, Ellman's method, gas chromatography-mass spectrometry
- MeSH terms
- Allylbenzene Derivatives, Anisoles, Cholinesterase Inhibitors, Humans, Phytotherapy, Plant Oils, Inhibitory Concentration 50, Rhizome, Acorus
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