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Cited by 39Growth Hormone and Insulin-like Growth FactorsBone health and osteoporosis researchHormonal and reproductive studies

Effects of Long-Term Treatment with GH in the Bone Mineral Density of Adults with Hypopituitarism and GH Deficiency and after Discontinuation of GH Replacement

Gómez, J., Gómez, N., Fiter, J., Soler, J.·2000·Hormone and Metabolic Research
DOI 10.1055/s-2007-978591
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Abstract

Background Only few previous studies have assessed the effects of long-term growth hormone (GH) replacement therapy on bone mineral density (BMD) in adult patients with GH deficiency. The aim of this study was to investigate the effects of long-term GH therapy on bone metabolism and BMD. Material and methods At the start of the study, 20 adults with GH deficiency were randomized to receive either GH, 0.25 IU x kg per week, or placebo. After 6 months, patients in the placebo group were switched to GH therapy, and they received GH for a further 18 months. Of the 20 patients, 14 were male and 6 female with GH deficiency of adult-onset. The mean age of the patients at the start of the study was 40.3+/-10.9 years and the duration of GH deficiency was 10.6+/-6.4 years. Patients deficient in pituitary hormones other than GH had been receiving stable replacement doses of appropriate hormones for at least 6 months before the start of the study. Rates of bone metabolism were assessed by measuring calcium, phosphate, alkaline phosphatase, calciuria, phosphaturia and osteocalcin. BMD was measured by dual X-ray absorptiometry. Body composition was calculated from measurements of bioelectrical impedance. Results Before GH treatment, BMD in the femoral neck was lower in patients than in controls. The rate of bone resorption markers increased significantly after 6 months and remained stable during the whole treatment period. BMD significantly increased in L2-L4 after 12 months of treatment w…

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  • Patients with isolated GH deficiency and with multiple pituitary deficiencies usually have low BMD.

    “Patients with isolated GH deficiency (GHD) and with multiple pituitary deficiencies usually have low BMD.”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [48]

  • GH may play a role in the achievement of peak bone mass.

    “which may present the potential role of GH in the achievement of peak bone mass [44–49].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [48]

  • After the first phase of GH treatment, bone turnover slows down and bone mass increases.

    “After this period bone turnover slows down and bone mass increases [48, 57, 58].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [48]

  • During rhGH treatment, BMD decreases within the first months and then increases after at least one year of therapy.

    “BMD within the first months of treatment decreased which was followed by a subsequent increase after at least one year of therapy.”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [48]

  • GH replacement promotes bone turnover by stimulating both bone formation and bone resorption, which is prominent during the first phase of GH treatment.

    “GH replacement promotes bone turnover by stimulating both bone formation and bone resorption, which is prominent during the first phase of GH treatment.”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [48]

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Authors
Gómez, J., Gómez, N., Fiter, J., & Soler, J.
Affiliations
Bellvitge University Hospital (ES)
ORCID
Gómez, J.
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2000-02
Volume
32
Issue
02
Pages
66-70
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2007-978591
OpenAlex
W2004820843
Cited by
39
References
0
Citations by year
2026: 1 · 2025: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 2
FWCI
3.14
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
growth hormone replacement therapy, adult-onset growth hormone deficiency, hypopituitarism, bone mineral density, bone metabolism, bone resorption markers, osteocalcin, urinary calcium excretion, phosphaturia, alkaline phosphatase, femoral neck, lumbar spine, body composition, insulin-like growth factor I, sex differences, long-term treatment
MeSH terms
Adult, Body Composition, Body Weight, Double-Blind Method, Edema, Female, Femur Neck, Humans, Hypertension, Hypopituitarism, Insulin-Like Growth Factor I, Male, Middle Aged, Osteoporosis, Biomarkers, Absorptiometry, Photon, Bone Density, Insulin-Like Growth Factor Binding Protein 3, Human Growth Hormone

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