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Mechanisms of the Glycaemic Effects of Sulfonylureas
Abstract
Sulfonylureas are widely used to treat non-insulin dependent diabetes mellitus. These drugs exert their hypoglycaemic effects by stimulating insulin secretion from the pancreatic beta-cell. Their primary mechanism of action is to close ATP-sensitive K-channels in the beta-cell plasma membrane, and so initiate a chain of events which results in insulin release. Recent studies have shown that the beta-cell ATP-sensitive K-channel is a complex of two proteins: a pore-forming subunit (Kir6.2) and a drug-binding subunit (SUR1) which functions as the receptor for sulfonylureas. This review summarizes recent advances in our understanding of the molecular mechanism of sulfonylurea action, focusing on the relationship between the sulfonylurea receptor and the K-ATP channel. Earlier studies are also re-examined in the light of new findings.
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Citations
Cited by
Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus
Inzucchi, S. E., Maggs, D. G., Spollett, G. R., Page, S. L., Rife, F. S., Walton, V., & Shulman, G. I. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381303 · Cited by 794
Activation of KATP channels by H2S in rat insulin‐secreting cells and the underlying mechanisms
Yang, W., Yang, G., Jia, X., Wu, L., & Wang, R. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.097642 · Cited by 469
Pathophysiology and Pharmacological Treatment of Insulin Resistance*
Matthaei, S., Stumvoll, M., Kellerer, M., & Häring, H.-U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0413 · Cited by 377
Effect of Obesogenic Medications on Weight‐Loss Outcomes in a Behavioral Weight‐Management Program
Desalermos, A., Russell, B., Leggett, C., Parnell, A., Ober, K., Hagerich, K., Gerlan, C., Ganji, G., Lee, E., Proudfoot, J. A., et al. (2019) · Obesity · doi:10.1002/oby.22444 · Cited by 47
Heller, S. R., Pratley, R. E., Sinclair, A., Festa, A., Kiljański, J., Brusko, C. S., Duan, R., & Heine, R. J. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13051 · Cited by 18
Metadata
- Authors
- Ashcroft, F.
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1996-09
- Volume
- 28
- Issue
- 09
- Pages
- 456-463
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2045506774
- Cited by
- 166
- References
- 0
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ashcroft, F. (1996). Mechanisms of the Glycaemic Effects of Sulfonylureas. Hormone and Metabolic Research. https://doi.org/10.1055/s-2007-979837
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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