The DOI matches its Crossref record; 428 of the 428 references it cites were found in a registry or an index.
Pathophysiology and Pharmacological Treatment of Insulin Resistance*
Open accessAbstract
Diabetes mellitus type 2 is a world-wide growing health problem affecting more than 150 million people at the beginning of the new millennium. It is believed that this number will double in the next 25 yr. The pathophysiological hallmarks of type 2 diabetes mellitus consist of insulin resistance, pancreatic β-cell dysfunction, and increased endogenous glucose production. To reduce the marked increase of cardiovascular mortality of type 2 diabetic subjects, optimal treatment aims at normalization of body weight, glycemia, blood pressure, and lipidemia. This review focuses on the pathophysiology and molecular pathogenesis of insulin resistance and on the capability of antihyperglycemic pharmacological agents to treat insulin resistance, i.e., α-glucosidase inhibitors, biguanides, thiazolidinediones, sulfonylureas, and insulin. Finally, a rational treatment approach is proposed based on the dynamic pathophysiological abnormalities of this highly heterogeneous and progressive disease.
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Cites
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Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Transcriptional Regulation of Metabolism
Desvergne, B., Michalik, L., & Wahli, W. (2006) · Physiological Reviews · doi:10.1152/physrev.00025.2005 · Cited by 892
Causes and Metabolic Consequences of Fatty Liver
Stefan, N., Kantartzis, K., & Häring, H.-U. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 532
Self-citationTang, T., Glanville, J., Hayden, C. J., White, D., Barth, J. H., & Balen, A. H. (2006) · Human Reproduction · doi:10.1093/humrep/dei311 · Cited by 335
Insulin resistance and obesity in childhood
Chiarelli, F., & Marcovecchio, M. L. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0245 · Cited by 285
Metadata
- Authors
- Matthaei, S., Stumvoll, M., Kellerer, M., & Häring, H.-U.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2000-12-01
- Volume
- 21
- Issue
- 6
- Pages
- 585-618
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2011419421
- Cited by
- 377
- References
- 428
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matthaei, S., Stumvoll, M., Kellerer, M., & Häring, H.-U. (2000). Pathophysiology and Pharmacological Treatment of Insulin Resistance*. Endocrine Reviews. https://doi.org/10.1210/edrv.21.6.0413
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
