The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Decidualization of the Human Endometrium: Mechanisms, Functions, and Clinical Perspectives
Abstract
The fetomaternal interface, consisting of the maternal decidua and the invading fetal trophoblast, critically regulates placental function and the growth and development of the conceptus. In its broadest sense, decidualization could be viewed as the postovulatory process of endometrial remodeling in preparation for pregnancy, which includes secretory transformation of the uterine glands, influx of specialized uterine natural killer cells, and vascular remodeling. A more restricted definition of the decidual process denotes the morphological and biochemical reprogramming of the endometrial stromal compartment. This differentiation process is dependent entirely on the convergence of the cyclic adenosine monophosphate and progesterone signaling pathways that drives integrated changes at both the transcriptome and the proteome level. As a consequence, decidualizing stromal cells acquire the unique ability to regulate trophoblast invasion, to resist inflammatory and oxidative insults, and to dampen local maternal immune responses. In humans, decidualization of the stromal compartment occurs in the mid-luteal phase of the menstrual cycle, independently of pregnancy. This raises the possibility that biochemical analysis of timed endometrial biopsy samples taken in a nonconception cycle could be informative of subsequent pregnancy outcome.
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Cites
Placental oxidative stress: from miscarriage to preeclampsia
Burton, G. J., & Jauniaux, E. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.03.003 · Cited by 673
Talbi, S., Hamilton, A. E., Vo, K. C., Tulac, S., Overgaard, M. T., Dosiou, C., Le Shay, N., Nezhat, C. N., Kempson, R., Lessey, B. A., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1076 · Cited by 589
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Kim, J. J., Taylor, H. S., Lu, Z., Ladhani, O., Hastings, J. M., Jackson, K. S., Wu, Y., Guo, S. W., & Fazleabas, A. T. (2007) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gam005 · Cited by 228
Uterine junctional zone, function and disease
Brosens, J. J., de Souza, N. M., & Barker, F. G. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91387-4 · Cited by 215 · cited 1×
“In addition, progesterone also attenuates the contractile activity of the junctional zone myocytes profoundly, a process that may be crucial for apposition of the blastocyst to the luminal epithelium.(6) However, the most striking aspect of the maternal response to pregnancy is the dramatic transformation of the endom…”
BackgroundDecorin prevents metastatic spreading of breast cancer
Reed, C. C., Waterhouse, A., Kirby, S., Kay, P., Owens, R. T., McQuillan, D. J., & Iozzo, R. V. (2005) · Oncogene · doi:10.1038/sj.onc.1208329 · Cited by 209
Cited by
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
Kim, J. J., Kurita, T., & Bulun, S. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1043 · Cited by 520
VEGF may contribute to macrophage recruitment and M2 polarization in the decidua
Wheeler, K. C., Jena, M. K., Pradhan, B. S., Nayak, N., Das, S., Hsu, C.-D., Wheeler, D. S., Chen, K., & Nayak, N. R. (2018) · PLOS ONE · doi:10.1371/journal.pone.0191040 · Cited by 258
Dyson, M. T., Roqueiro, D., Monsivais, D., Ercan, C. M., Pavone, M. E., Brooks, D. C., Kakinuma, T., Ono, M., Jafari, N., Dai, Y., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004158 · Cited by 211
Mechanisms of endometrial progesterone resistance
Al-Sabbagh, M., Lam, E. W.-F., & Brosens, J. J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.035 · Cited by 183
Self-citationA role for menstruation in preconditioning the uterus for successful pregnancy
Brosens, J. J., Parker, M. G., McIndoe, A., Pijnenborg, R., & Brosens, I. A. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.11.037 · Cited by 166
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Metadata
- Authors
- Gellersen, B., Brosens, I., & Brosens, J.
- Venue
- Seminars in Reproductive Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2007-11
- Volume
- 25
- Issue
- 6
- Pages
- 445-453
- ISSN
- 1526-4564 (ISSN-L)
- 1526-8004
- OpenAlex
- W2049014099
- Cited by
- 587
- References
- 5
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
