Evolving Concepts of Oxytocin for Induction of Labor
Abstract
Based on findings of maternal and fetal circulating oxytocin levels during spontaneous labor and the available information on oxytocin secretion patterns, the dosage and mode of administration of oxytocin for induction of labor is discussed. It is recommended that intravenous infusion rates should not exceed 2 to 8 mU/min. Oxytocin administered in a pulsatile fashion beginning with 1 mU/min every 8 minutes with doubling the pulse dose every 24 minutes is equally as efficient as continuous infusion. Because both the peak levels and the total dose of oxytocin needed for induction are lower with pulsatile than continuous administration, the risk of adverse effects for the mother and the fetus is significantly reduced.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
By the 1980s, many laboratories had generated radioimmunoassays for oxytocin using independently produced antibodies, and most but not all required extraction.
“By the 1980s, many laboratories had generated radioimmunoassays for oxytocin, using independently produced antibodies 58, 72, 73, 74, 94, 95, 96, 97, 98] and most, but not all 99, 100, required extraction.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [58]
Cited by
Sorted by citations
Uvnäs‐Moberg, K., Ekström, A., Berg, M., Buckley, S. J., Pajalić, Z., Hadjigeorgiou, E., Kotłowska, A., Lengler, L., Kiełbratowska, B., León-Larios, F., et al. (2019) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-019-2365-9 · Cited by 296 · see citing works
Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237 · see citing works
“Dawood (58) advised that infusions should not exceed 2–8 mU/min and reported that oxytocin given as pulses, beginning with 1 mU/min every 8 min and doubling the pulse dose every 24 min, was as efficient as continuous infusion.”
BackgroundFuchs, A., Romero, R. J., Keefe, D. L., Parra, M., Enrique Oyarzún, E., & Behnke, E. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90399-c · Cited by 205 · see citing works
Oxytocin and its receptor in pregnancy and parturition: Current concepts and clinical implications
Zeeman, G. G. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00056-2 · Cited by 161 · see citing works
The discovery of GSK221149A: A potent and selective oxytocin antagonist
Liddle, J., Allen, M. J., Borthwick, A. D., Brooks, D. P., Davies, D. E., Edwards, R. M., Exall, A. M., Hamlett, C. C. F., Irving, W. R., Mason, A. M., et al. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.11.008 · Cited by 91 · see citing works
Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section
Sarna, M. C., Soni, A. K., Gómez, M., & Oriol, N. E. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199704000-00010 · Cited by 61 · see citing works
Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section
Sarna, M. C., Soni, A. K., Gómez, M., & Oriol, N. E. (1997) · Anesthesia & Analgesia · doi:10.1213/00000539-199704000-00010 · Cited by 54 · see citing works
Oxytocics in developing countries
Dujardin, B., Boutsen, M., Schampheleire, I. D., Külker, R., Manshande, J. P., Bailey, J., Wollast, E., & Buekens, P. M. (1995) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(95)02389-t · Cited by 30 · see citing works
Wyatt, P. G., Allen, M. J., Chilcott, J., Foster, A. J., Livermore, D. G., Mordaunt, J. E., Scicinski, J. J., & Woollard, P. M. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00159-2 · Cited by 30 · see citing works
8 The endocrinology of parturition in the human
Steer, P. J. (1990) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80054-0 · Cited by 22 · see citing works
Variations in oxytocin regimes in Scottish labour wards in 1998
N. Arnott, A. J. H. (2000) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610050009502 · Cited by 6 · see citing works
Oxytocin and the augmentation of labor
Curtis, P. (1993) · Human Nature · doi:10.1007/bf02692246 · Cited by 6 · see citing works
Rational for the Revision of Oxytocin Administration protocol
Brodsky, P. L., & Pelzar, E. M. (1991) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.1991.tb01708.x · Cited by 5 · see citing works
Sørensen, H. T., Rothman, K. J., Gillman, M. W., Steffensen, F. H., Fischer, P., & Sabroe, S. (1999) · BMJ · doi:10.1136/bmj.318.7181.433 · Cited by 3 · see citing works
Perdomo, O. B., Sucre, P. G., Marquina, S. D. V., & Guerra, G. B. (2007)
von Bruchhausen, F., Ebel, S., Hackenthal, E., Dannhardt, G., Frahm, A. W., Holzgrabe, U., Keller, K., Nürnberg, E., Rimpler, H., Schneider, G., et al. (1993) · Springer eBooks · doi:10.1007/978-3-642-57994-3_11
BindingDB Entry 50038167: The discovery of GSK221149A: a potent and selective oxytocin antagonist.
BindingDB (2012) · UC San Diego · doi:10.7270/q2xd12h2
Steroid Modulation of Myometrial Structure and Function During Pregnancy
Ducsay, C. A., & Rhee, J. W. (1996) · Advances in organ biology · doi:10.1016/s1569-2590(08)60072-5
- Authors
- Dawood, M.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Dawood, M.
- Venue
- American Journal of Perinatology
- Publisher
- Georg Thieme Verlag KG
- Published
- 1989-04
- Volume
- 6
- Issue
- 02
- Pages
- 167-172
- ISSN
- 0735-1631 (ISSN-L)
- 1098-8785
- OpenAlex
- W2069537217
- Cited by
- 17
- References
- 0
- Citations by year
- 2019: 1 · 2016: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- oxytocin, labor induction, pulsatile administration, continuous infusion, intravenous infusion rate
- MeSH terms
- Cervix Uteri, Dose-Response Relationship, Drug, Female, Humans, Infusions, Intravenous, Injections, Intravenous, Labor, Induced, Oxytocin, Pregnancy, Prostaglandins, Uterine Contraction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
