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Cited by 1,221

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Intravenous Infusion of Bone Marrow in Patients Receiving Radiation and Chemotherapy

Thomas, E. Donnall, Lochte, Harry L., Lu, Wan Ching, Ferrebee, Joseph W.·1957·New England Journal of Medicine

Abstract

AFTER a lethal dose of radiation in rodents,1 canines2 or primates,3 the destroyed bone marrow may be repopulated by intravenous infusion of cellular suspensions of marrow taken from healthy isologous, homologous4 and, in some cases, heterologous3 donors. Effective cells for these infusions may be stored by the Polge technic of freezing to -80°C. in glycerol.6 Hosts seeded with donor marrow have some of the immunologic characteristics of the donors, and in some circumstances will take and hold homografts of other organs from them.7 Since cases of radiation disaster may occur, and since bone-marrow deficiency from radiation or chemotherapy does occur . . .

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Metadata

Authors
Thomas, E. D., Lochte, H. L., Lu, W. C., & Ferrebee, J. W.
Venue
New England Journal of Medicine
Published
1957-09-12
Volume
257
Issue
11
Pages
491-496
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2075580305
Cited by
1,221
References
0
FWCI
24.06
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Intravenous Infusion of Bone Marrow in Patients Receiving Radiation and Chemotherapy. https://app.cochat.ai/papers/10.1056/nejm195709122571102
The paper
Thomas, E. D., Lochte, H. L., Lu, W. C., & Ferrebee, J. W. (1957). Intravenous Infusion of Bone Marrow in Patients Receiving Radiation and Chemotherapy. New England Journal of Medicine. https://doi.org/10.1056/nejm195709122571102

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.