The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Extracellular Vesicles: Potential Roles in Regenerative Medicine
Open accessAbstract
Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the multivesicular body with the cell membrane, and microvesicles, which are released directly from the cell membrane. EV can mediate cell-cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. The vast amount of processes that EV are involved in and the versatility of manner in which they can influence the behavior of recipient cells make EV an interesting source for both therapeutic and diagnostic applications. Successes in the fields of tumor biology and immunology sparked the exploration of the potential of EV in the field of regenerative medicine. Indeed, EV are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation. In this review, we discuss the function and role of EV in regenerative medicine and elaborate on potential applications in tissue engineering.
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Cites
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Physical exercise induces rapid release of small extracellular vesicles into the circulation
Frühbeis, C., Helmig, S., Tug, S., Simon, P., & Krämer‐Albers, E. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.28239 · Cited by 360
Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020171 · Cited by 301
Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake
Zhao, X., Wu, D., Ma, X., Wang, J., Hou, W., & Zhang, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110237 · Cited by 197
Metadata
- Authors
- De Jong, O. G., Van Balkom, B. W. M., Schiffelers, R. M., Bouten, C. V. C., & Verhaar, M. C.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014-12-03
- Volume
- 5
- Pages
- 608-608
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2049511775
- Cited by
- 351
- References
- 137
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- gold
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