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Defining Adult Stem Cells by Function, not by Phenotype

Clevers, Hans, Watt, Fiona M.·2018·Annual Review of Biochemistry
DOI 10.1146/annurev-biochem-062917-012341
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Abstract

Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the transplantable HSC. The HSC paradigm has served as a stereotypic template in stem cell biology, yet the search for rare, hardwired professional stem cells has remained futile in most other tissues. In a more open approach, the focus on the search for stem cells as a physical entity may need to be replaced by the search for stem cell function, operationally defined as the ability of an organ to replace lost cells. The nature of such a cell may be different under steady state conditions and during tissue repair. We discuss emerging examples including the renewal strategies of the skin, gut epithelium, liver, lung, and mammary gland in comparison with those of the hematopoietic system. While certain key housekeeping and developmental signaling pathways are shared between different stem cell systems, there may be no general, deeper principles underlying the renewal mechanisms of the various individual tissues.

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Research works printed but not linked: 56

  1. Lorenz E, 1951, J. Natl. Cancer Inst., 12, 197
  2. 10.1056/NEJM195709122571102 · DOI
  3. 10.2307/3570892 · DOI
  4. 10.1182/blood-2014-12-570200 · DOI
  5. 10.4049/jimmunol.1400902 · DOI
  6. 10.1146/annurev.cb.11.110195.000343 · DOI
  7. 10.1073/pnas.81.8.2520 · DOI
  8. 10.1016/S0092-8674(00)80643-1 · DOI
  9. 10.1101/gad.242511.114 · DOI
  10. 10.1007/BF00225420 · DOI
  11. 10.1242/jcs.1988.Supplement_10.4 · DOI
  12. 10.1111/j.1087-0024.2004.09313.x · DOI
  13. 10.1016/j.stem.2012.04.001 · DOI
  14. 10.1016/j.cell.2013.07.004 · DOI · Paper page
  15. 10.1038/ncb2581 · DOI
  16. 10.1016/j.stem.2017.05.001 · DOI
  17. 10.1016/j.stem.2016.01.001 · DOI · Paper page
  18. 10.1242/dev.143784 · DOI · Paper page
  19. 10.1016/j.stem.2015.01.002 · DOI
  20. 10.1016/j.stem.2009.04.002 · DOI
  21. 10.1038/nature12777 · DOI
  22. 10.1038/nature12930 · DOI
  23. 10.1016/j.cell.2013.09.008 · DOI
  24. 10.1038/ncb3541 · DOI
  25. 10.1038/ncb3532 · DOI
  26. 10.1016/0092-8674(75)90183-X · DOI
  27. 10.1016/S0140-6736(81)90006-4 · DOI
  28. 10.1056/NEJM198408163110706 · DOI
  29. 10.1073/pnas.84.8.2302 · DOI
  30. 10.1016/0092-8674(93)90251-K · DOI
  31. 10.1242/dev.00703 · DOI · Paper page
  32. 10.1111/j.1365-2184.1994.tb01425.x · DOI · Paper page
  33. 10.1126/science.1218835 · DOI
  34. 10.1016/j.cell.2010.09.016 · DOI · Paper page
  35. 10.1126/science.1196236 · DOI
  36. 10.1016/j.celrep.2013.09.025 · DOI
  37. 10.1016/j.stem.2010.05.017 · DOI
  38. Schofield R., 1978, Blood Cells, 4, 7
  39. 10.1038/nature04496 · DOI
  40. 10.1038/nature12948 · DOI
  41. 10.1038/nature13851 · DOI
  42. 10.1530/ERC-15-0195 · DOI
  43. 10.1038/nm1328 · DOI
  44. 10.1002/emmm.200900033 · DOI
  45. 10.1016/j.stem.2015.04.014 · DOI
  46. 10.1038/nature11393 · DOI
  47. 10.1016/j.stemcr.2013.04.001 · DOI
  48. 10.1038/ncb3359 · DOI
  49. 10.1146/annurev-physiol-021113-170255 · DOI · Paper page
  50. 10.1016/j.stem.2014.04.010 · DOI · Paper page
  51. 10.1093/carcin/8.11.1737 · DOI
  52. 10.1016/j.stem.2014.08.004 · DOI
  53. 10.1016/j.stem.2014.06.003 · DOI · Paper page
  54. 10.1016/j.stemcr.2017.06.003 · DOI
  55. 10.1126/science.aad7016 · DOI
  56. 10.1101/cshperspect.a013631 · DOI

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Metadata

Authors
Clevers, H., & Watt, F. M.
Affiliations
  • Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Princess Máxima Center for Pediatric Oncology and University Medical Center Utrecht, 3584CT Utrecht, The Netherlands;
  • Centre for Stem Cells and Regenerative Medicine, King's College London, London SE1 9RT, United Kingdom;
Venue
Annual Review of Biochemistry
Publisher
Annual Reviews
Published
2018-06-20
Volume
87
Issue
1
Pages
1015-1027
ISSN
  • 0066-4154
  • 1545-4509
DOI
10.1146/annurev-biochem-062917-012341
Cited by
245
References
17
Language
en

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