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Subarachnoid Distribution of Drugs after Lumbar Injection
Abstract
DIRECT injection of drugs into the subarachnoid space is required for treatment of several diseases involving the leptomeninges. This is necessary because of the virtual exclusion of certain plasma constituents by the bloodcerebrospinal-fluid barrier due to molecular size, protein binding, lipid insolubility or ionization.2 Drugs included in this category are polymyxin B and amphotericin B.3 , 4 The antimetabolites 6-mercaptopurine and methotrexate, used in the therapy of acute leukemia, do not attain significant levels in spinal fluid when administered systemically.2 , 5 Therefore, meningeal leukemia, the diffuse involvement of the meninges by leukemic cells, must often be treated with an intrathecally administered drug such . . .
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Citations
Cited by
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Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219
Hinderer, C., Bell, P., Katz, N., Vite, C. H., Louboutin, J.-P., Bote, E., Yu, H., Zhu, Y., Casal, M. L., Bagel, J., et al. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.026 · Cited by 141
Calias, P., Papisov, M., Pan, J., Savioli, N., Belov, V., Huang, Y., Lotterhand, J., Alessandrini, M., Liu, N., Fischman, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030341 · Cited by 133
Papisov, M. I., Belov, V. V., & Gannon, K. S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300474m · Cited by 97
Metadata
- Authors
- Rieselbach, R. E., Chiro, G. D., Freireich, E. J., & Rall, D. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1962-12-20
- Volume
- 267
- Issue
- 25
- Pages
- 1273-1278
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2016373621
- Cited by
- 213
- References
- 0
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rieselbach, R. E., Chiro, G. D., Freireich, E. J., & Rall, D. P. (1962). Subarachnoid Distribution of Drugs after Lumbar Injection. New England Journal of Medicine. https://doi.org/10.1056/nejm196212202672502
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