Transport of drugs from the nasal cavity to the central nervous system

Illum, Lisbeth

doi:10.1016/s0928-0987(00)00087-7

Cited by 907Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Transport of drugs from the nasal cavity to the central nervous system

Illum, Lisbeth·2000·European Journal of Pharmaceutical Sciences

DOI 10.1016/s0928-0987(00)00087-7

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Because intra-neuronal transport of neuropeptides from the nasal cavity to the olfactory bulb takes several hours, intranasally administered peptides are more likely primarily transported along extra-neuronal routes.
“The intra-neuronal transport of neuropeptides from the nasal cavity to the olfactory bulb takes several hours, 29 which makes it more likely that IN administered peptides are primarily transported along extra-neuronal routes (ie, through intercellular clefts of the olfactory epithelium).”
From Intranasal insulin (2021) · cites this paper as [32]

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Authors: Illum, L.
Affiliations: West Pharmaceutical Services (United Kingdom) (GB)
Corresponding author: Illum, Lisbeth
Venue: European Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2000-07
Volume: 11
Issue: 1
Pages: 1-18
ISSN: 0928-0987 (ISSN-L)
DOI: 10.1016/s0928-0987(00)00087-7
OpenAlex: W2114179943
Cited by: 907
References: 91
Citations by year: 2026: 45 · 2025: 37 · 2024: 36 · 2023: 45 · 2022: 36 · 2021: 50 · 2020: 44 · 2019: 35 · 2018: 36 · 2017: 38 · 2016: 44 · 2015: 40 · 2014: 51 · 2013: 51 · 2012: 39
FWCI: 2.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: HIV, HIV reservoir, intranasal drug delivery, nose-to-brain transport, antiretroviral drugs, olfactory pathway, trigeminal pathway, efflux pumps, bioavailability
MeSH terms: Administration, Intranasal, Animals, Brain, Central Nervous System, Humans, Meninges, Nasal Cavity, Olfactory Mucosa, Pharmacokinetics

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