Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 316

The DOI matches its Crossref record.

Studies on the Epidemiology of Adverse Drug Reactions: An Evaluation of Penicillin Allergy

Smith, Jay W., Johnson, Joseph E., Cluff, Leighton E.·1966·New England Journal of Medicine

Abstract

THE remarkable lack of pharmacologic toxicity of penicillin is now well established, but penicillin hypersensitivity reactions have become a serious problem. A projection of statistics from some surveys estimates that 100 to 300 fatalities occur annually in the United States from reactions to penicillin,1 and an estimated 2,500,000 people in the United States are allergic to this widely used antibiotic.2 Adverse reactions to penicillin occur in 1 to 8 per cent of patients treated.3 The different reaction rates are probably related to numerous factors, including the difficulty in attributing reactions specifically to penicillin, particularly when several drugs are being administered . . .

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejm196605052741804

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cited by

See all 316

Metadata

Authors
Smith, J. W., Johnson, J. E., & Cluff, L. E.
Venue
New England Journal of Medicine
Published
1966-05-05
Volume
274
Issue
18
Pages
998-1002
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W1988984702
Cited by
316
References
0
FWCI
12.14
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Studies on the Epidemiology of Adverse Drug Reactions: An Evaluation of Penicillin Allergy. https://app.cochat.ai/papers/10.1056/nejm196605052741804
The paper
Smith, J. W., Johnson, J. E., & Cluff, L. E. (1966). Studies on the Epidemiology of Adverse Drug Reactions: An Evaluation of Penicillin Allergy. New England Journal of Medicine. https://doi.org/10.1056/nejm196605052741804

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.