Studies on the Epidemiology of Adverse Drug Reactions: V. Clinical Factors Influencing Susceptibility

Abstract

Article1 October 1966Studies on the Epidemiology of Adverse Drug ReactionsV. Clinical Factors Influencing SusceptibilityJAY W. SMITH, M.D., LARRY G. SEIDL, M.D., LEIGHTON E. CLUFF, M.D., F.A.C.P.JAY W. SMITH, M.D., LARRY G. SEIDL, M.D., LEIGHTON E. CLUFF, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-629 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAdverse pharmacological effects or allergic reactions produced by drugs are determined not only by differences among drugs but also by differences among individuals. Some of the personal or clinical variables and factors influencing drug effects are known, but for the most part it has not been possible to predict which patients are most likely to have adverse reactions after administration of a drug or drugs. The epidemiological studies reported here have been done to examine these personal variables or clinical factors which may be responsible for predisposition to the untoward effects of drugs. The observations define some of these factors,...References1. SEIDLTHORNTONSMITHCLUFF LGGFJWLE: Studies on the epidemiology of adverse drug reactions. III. Reactions in patients on a general medical service. Bull. Hopkins Hosp. 119, in press, 1966. Google Scholar2. GREEN DM: Pre-existing conditions, placebo reactions, and "side effects." Ann. Intern. Med. 60: 255, 1964. LinkGoogle Scholar3. DINGLEBADGERJORDAN JHGFWS: Gastrointestinal Illnesses in Illness in the Home. The Press of Western Reserve University, Cleveland, 1964, pp. 188-218. Google Scholar4. SMITHJOHNSONCLUFF JWJELE: Studies on the epidemiology of adverse drug reactions. II. An evaluation of penicillin allergy. New Eng. J. Med. 274: 998, 1966. CrossrefMedlineGoogle Scholar5. BERTIDIMASECHRISTIANSON SJJDCS: Isoniazid, para-aminosalicyclic acid, and streptomycin intolerance in 1,744 patients. An analysis of reactions to single drugs and drug groups plus data on multiple reactions, type and time of reactions, and desensitization. Amer. Rev. Resp. Dis. 90: 598, 1964. MedlineGoogle Scholar6. LOWNMARCUSLEVINE BFHD: Digitalis and atrial tachycardia with block. New Eng. J. Med. 260: 301, 1959. CrossrefMedlineGoogle Scholar7. HAY G: Severe reaction to monoamine-oxidase inhibitor in a dexamphetamine addict. Lancet 2: 665, 1962. CrossrefGoogle Scholar8. CUCINELLCONNEYSANSUR SAAHM: Drug interactions in man. I. Lowering effect of phenobarbital on plasma levels of bishydroxycoumarin (Dicumarol) and diphenylhydantoin (Dilantin). Clin. Pharm. Ther. 6: 420, 1965. CrossrefMedlineGoogle Scholar9. CHRISTENSENHANSENKRISTENSEN LKJMM: Sulphaphenazole-induced hypoglycaemic attacks in tolbutamide-treated diabetics. Lancet 2: 1298, 1963. CrossrefMedlineGoogle Scholar10. GOODMANGILMAN LSA: The Pharmacological Basis of Therapeutics. The MacMillan Co., New York, 1965. Google Scholar11. DOHERTYPERKINSWILSON JEWHMC: Studies with tritiated digoxin in renal failure. Amer. J. Med. 37: 536, 1964. CrossrefMedlineGoogle Scholar12. PACKMANUTIGER RCRD: Manual of Medical Therapeutics. Little, Brown and Co., Waltham, Mass., 1964. Google Scholar13. SMALLLONGARINIZAMCHECK MDAEN: Observations of liver function in chlorpromazine-treated alcoholic patients. New Eng. J. Med. 256: 932, 1957. CrossrefMedlineGoogle Scholar14. LAIDLAWREADSHERLOCK JAES: Morphine tolerance in hepatic cirrhosis. Gastroenterology 40: 389, 1961. CrossrefMedlineGoogle Scholar15. FUHRMANFUHRMAN GFFA: Effects of temperature on the action of drugs. Ann. Rev. Pharm. 1: 65, 1961. CrossrefGoogle Scholar16. HOLLISTER LE: Adverse reactions to drugs. Postgrad. Med. 37: 94, 1965. CrossrefMedlineGoogle Scholar17. ALEXANDER HL: Reactions with Drug Therapy. W. B. Saunders Co., Philadelphia, 1955, p. 8. Google Scholar18. THOBURNJOHNSONCLUFF RJELE: Studies on the epidemiology of adverse drug reactions. IV. Reactions to cephalothin in patients with penicillin hypersensitivity. JAMA. In press. Google Scholar19. HARVEYSHULMANTUMULTYCONLEYSCHROENRICH AMLEPALEEH: Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Balt.) 33: 291, 1954. CrossrefMedlineGoogle Scholar20. ROMAN G: Sur la production des antitoxines. C. R. Acad. Sci. (Paris) 181: 157, 1925. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAY W. SMITH, M.D.; LARRY G. SEIDL, M.D.; LEIGHTON E. CLUFF, M.D., F.A.C.P.Affiliations: Baltimore, Maryland, and Gainesville, FloridaFrom the Johns Hopkins University School of Medicine, Baltimore, Md., and the University of Florida College of Medicine, Gainesville, Fla.This study was supported by a program project grant from the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, Md.Drs. Smith and Seidle were Epidemic Intelligence Service Officers of the USPHS, CDC, assigned as Resear