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Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital
Abstract
GLUCURONIDE conjugation is an important mechanism for the elimination of endogenous and exogenous substances from the human body.1 A defect in this mechanism leads to increased concentrations of unconjugated bilirubin in the blood, and the latter is therefore frequently a reflection of impaired glucuronide synthesis.2 Patients with unusually low capacity for the conjugation of bilirubin show a similar reduced capacity for glucuronide conjugation of certain drugs that are ordinarily metabolized and eliminated by that process.3 , 4 Congenital, nonobstructive, nonhemolytic jaundice, which is thought to be due to a functional impairment of the glucuronyl transferase system, presents a particularly serious and difficult . . .
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Citations
Cited by
Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR
Tolson, A. H., & Wang, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.006 · Cited by 386
Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency
Arias, I. M., Gartner, L. M., Cohen, M., Ezzer, J. B., & Levi, A. J. (1969) · The American Journal of Medicine · doi:10.1016/0002-9343(69)90224-1 · Cited by 340
Drummond, G. S., & Kappas, A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6466 · Cited by 279
Conney, A. H., & Burns, J. J. (1972) · Science · doi:10.1126/science.178.4061.576 · Cited by 260
The xenobiotic receptors PXR and CAR in liver physiology, an update
Cai, X., Young, G. M., & Xie, W. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166101 · Cited by 84
Metadata
- Authors
- Yaffe, S. J., Levy, G., Matsuzawa, T., & Baliah, T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1966-12-29
- Volume
- 275
- Issue
- 26
- Pages
- 1461-1466
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2614806950
- Cited by
- 261
- References
- 0
- FWCI
- 52.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital. https://app.cochat.ai/papers/10.1056/nejm196612292752602
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- Yaffe, S. J., Levy, G., Matsuzawa, T., & Baliah, T. (1966). Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital. New England Journal of Medicine. https://doi.org/10.1056/nejm196612292752602
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
