The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs.
Abstract
It is evident that metabolic interactions can occur among drugs, insecticides, food additives, carcinogenic hydrocarbons, and a variety of environmental chemicals. A common denominator governing these effects is the versatile nature of the liver microsomal enzymes that metabolize chemicals with diverse structures and biological activities, and the fact that these enzymes can be stimulated or inhibited by other chemicals administered simultaneously. The discovery of these particular enzymes in the 1950's laid the groundwork for the current research on metabolic interactions. Such research provides information that is helpful in the evaluation of the safety and efficacy of drugs and environmental chemicals, and suggests new directions for further research. Some examples are as follows.
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Citations
Cites
PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION
CONNEY, A. H. (1967) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07146-7 · Cited by 2,951
Self-citationPolychlorinated Biphenyls in the Global Ecosystem
RISEBROUGH, R. W., RIECHE, P., PEAKALL, D. B., HERMAN, S. G., & KIRVEN, M. N. (1968) · Nature · doi:10.1038/2201098a0 · Cited by 730
Nitrosamines as Environmental Carcinogens
LIJINSKY, W., & EPSTEIN, S. S. (1970) · Nature · doi:10.1038/225021a0 · Cited by 672
DIETARY FAT AND DIETARY SUGAR IN RELATION TO ISCHÆMIC HEART-DISEASE AND DIABETES
Yudkin, J. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90002-9 · Cited by 669
ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS
Conney, A. H., Davison, C., Gastel, R., & Burns, J. J. (1960) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25856-6 · Cited by 533
Self-citationPhotochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems
Cooper, D. Y., Levin, S., Narasimhulu, S., Rosenthal, O., & Estabrook, R. W. (1965) · Science · doi:10.1126/science.147.3656.400 · Cited by 501
Substrate-Induced Synthesis And Other Properties Of Benzpyrene Hydroxylase In Rat Liver
Conney, A. H., Miller, E. C., & Miller, J. A. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70657-1 · Cited by 467
Self-citationThe Upjohn Lecture of the Endocrine Society Sex Hormones, Brain Development and Brain Function12
HARRIS, G. W. (1964) · Endocrinology · doi:10.1210/endo-75-4-627 · Cited by 450
Osteomalacia with Long-term Anticonvulsant Therapy in Epilepsy
Dent, C. E., Richens, A., Rowe, D. J., & Stamp, T. C. B. (1970) · BMJ · doi:10.1136/bmj.4.5727.69 · Cited by 423
Nebert, D. W., & Gelboin, H. V. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90253-7 · Cited by 420
Cited by
Strategies in Herbivory by Mammals: The Role of Plant Secondary Compounds
Freeland, W. J., & Janzen, D. H. (1974) · The American Naturalist · doi:10.1086/282907 · Cited by 1,358
Metadata
- Authors
- Conney, A. H., & Burns, J. J.
- Venue
- Science
- Published
- 1972-11-10
- Volume
- 178
- Issue
- 4061
- Pages
- 576-586
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992240306
- Cited by
- 260
- References
- 81
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs. https://app.cochat.ai/papers/10.1126/science.178.4061.576
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- Conney, A. H., & Burns, J. J. (1972). Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs. Science. https://doi.org/10.1126/science.178.4061.576
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
