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Arterial-Blood Gas Tension in Asthma
Abstract
Arterial oxygen and carbon dioxide tensions, pH and forced expiratory volumes were measured in 101 asthmatic patients during acute attacks of bronchospasm. Hypoxemia was observed in 91 subjects. The cause of the depressed oxygen tensions was found to be an alteration in ventilation-perfusion ratios. Overall alveolar hypoventilation and increased venous admixture were found to contribute to the hypoxemia in some patients with very severe levels of airway obstruction. Seventy-three subjects had hypocarbia and respiratory alkalosis. Carbon dioxide retention (observed in 11 patients) occurred only at extreme degrees of obstruction. Age, history of asthma and duration of the acute attack were unrelated to the alterations in blood gas tensions, pH or severity of airway obstruction.
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Citations
Cited by
The Pathophysiology of Hyperventilation Disorders
Gardner, W. N. (1996) · Chest · doi:10.1378/chest.109.2.516 · Cited by 312
Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects
van den Elshout, F. J., van Herwaarden, C. L., & Folgering, H. T. (1991) · Thorax · doi:10.1136/thx.46.1.28 · Cited by 128
Respiratory and psychiatric abnormalities in chronic symptomatic hyperventilation
Bass, C., & Gardner, W. N. (1985) · BMJ · doi:10.1136/bmj.290.6479.1387 · Cited by 125
Hyperventilation in panic disorder and asthma: Empirical evidence and clinical strategies
Meuret, A. E., & Ritz, T. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.006 · Cited by 118
Hyperventilation and asymptomatic chronic asthma
Osborne, C. A. (2000) · Thorax · doi:10.1136/thorax.55.12.1016 · Cited by 75
Metadata
- Authors
- McFadden, E. R., & Lyons, H. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1968-05-09
- Volume
- 278
- Issue
- 19
- Pages
- 1027-1032
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2006297837
- Cited by
- 363
- References
- 0
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- McFadden, E. R., & Lyons, H. A. (1968). Arterial-Blood Gas Tension in Asthma. New England Journal of Medicine. https://doi.org/10.1056/nejm196805092781901
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