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Cited by 128Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory Support and Mechanisms

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Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects

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van den Elshout, F. J., van Herwaarden, C. L., Folgering, H. T.·1991·Thorax
DOI 10.1136/thx.46.1.28PMC PMC1020910
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Abstract

The effects of hypercapnia and hypocapnia on respiratory resistance were studied in 15 healthy subjects and 30 asthmatic subjects. Respiratory resistance (impedance) was measured with the pseudo-random noise forced oscillation technique while the subjects rebreathed from a wet spirometer in a closed respiratory circuit in which end tidal carbon dioxide tension (PCO2) could be controlled. Hypercapnia was induced by partially short circuiting the carbon dioxide absorber, and hypocapnia by voluntary hyperventilation. The circulating air was saturated with water vapour and kept at body temperature and ambient pressure. A rise of end tidal PCO2 of 1 kPa caused a significant fall in respiratory resistance in both normal and asthmatic subjects (15% and 9% respectively). A fall of PCO2 of 1 kPa did not cause any significant change in impedance in the control group. In the asthmatic patients resistance increased by 13%, reactance fell by 45%, and the frequency dependence of resistance rose 240%. These findings confirm that hypocapnia may contribute to airway obstruction in asthmatic patients, even when water and heat loss are prevented.

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Research works printed but not linked: 33

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Metadata

Authors
van den Elshout, F. J., van Herwaarden, C. L., & Folgering, H. T.
Affiliations
Radboud University Nijmegen (NL)
Venue
Thorax
Publisher
BMJ
Published
1991-01-01
Volume
46
Issue
1
Pages
28-32
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.46.1.28
PMC
PMC1020910
OpenAlex
W2045789922
Cited by
128
References
0
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
0.87
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
hypercapnia, hypocapnia, respiratory resistance, asthma, airway obstruction, end-tidal carbon dioxide, forced oscillation technique, reactance, hyperventilation, carbon dioxide absorber
MeSH terms
Adult, Airway Resistance, Asthma, Carbon Dioxide, Female, Humans, Hypercapnia, Male, Oscillometry

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CoChat. (2026). Citation check: Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects. https://app.cochat.ai/papers/10.1136/thx.46.1.28
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van den Elshout, F. J., van Herwaarden, C. L., & Folgering, H. T. (1991). Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects. Thorax. https://doi.org/10.1136/thx.46.1.28