CoChat
Sign Up
Cited by 350Hypothalamic control of reproductive hormonesReproductive Biology and FertilitySexual Differentiation and Disorders

Age at Menarche: Genetic and Environmental Influences

Zacharias, Leona, Wurtman, Richard J.·1969·New England Journal of Medicine
DOI 10.1056/nejm196904172801606
Open this paper in CoChat — free account

Abstract

CLINICIANS are often asked by concerned parents whether their daughter's age at menarche is abnormally late — or abnormally early. In answer, it may be said that what is normal for a particular girl depends upon her genes and life history as well as the common characteristic of human females to start to menstruate at sometime during the second decade of life.For each species of mammal, a characteristic period elapses between birth and the development of full sexual function. In normal girls evidence of sexual maturation characteristically appears not at four or 40, but at eight or 10 or . . .

Integrity signals

Registry

Crossref · 10.1056/nejm196904172801606

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Data showing an association between the ages at which a mother and her children attain pubertal milestones and between the timing of puberty within ethnic groups are suggestive of genetic modulation of the reproductive endocrine axis.

    “Data showing an association between the ages at which a mother and her children attain pubertal milestones and between the timing of puberty within ethnic groups are suggestive of genetic modulation of the reproductive endocrine axis.23,41”

    From Pubertal development and regulation (2016) · cites this paper as [41]

  • The decrease in the average age of puberty initiation between the mid-19th and mid-20th centuries suggested an association of nutrition and environmental factors with reproduction.

    “The decrease in the average age of puberty initiation between the mid-19th and mid-20th centuries suggested an association of nutrition and environmental factors with reproduction,20,41”

    From Pubertal development and regulation (2016) · cites this paper as [41]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Zacharias, L., & Wurtman, R. J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1969-04-17
Volume
280
Issue
16
Pages
868-875
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm196904172801606
OpenAlex
W2035671142
Cited by
350
References
32
Citations by year
2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 52 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 10
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
age at menarche, menarche, puberty, sexual maturation, adolescent girls, life history, genetic factors
MeSH terms
Adolescent, Adult, Age Factors, Aging, Altitude, Child, Disease, Environment, Family Characteristics, Female, Genetics, Medical, Geography, Growth, Humans, Humidity, Light, Menstruation, Nutritional Physiological Phenomena, Psychosomatic Medicine, Rural Health, Seasons, Socioeconomic Factors, Temperature, Urban Population, Racial Groups

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review