The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Multiple Myeloma and Acute Myelomonocytic Leukemia: Report of Four Cases Possibly Related to Melphalan
Abstract
A rapidly progressive acute myelomonocytic leukemia developed in four patients who had received prolonged courses of melphalan, ranging from 30 to 57 months. Three patients were being treated for typical multiple myeloma (anemia, elevated sedimentation rate, monoclonal serum peak, Bence-Jones protein in the urine, lytic bone lesions and increased numbers of myeloma cells in the marrow), and one for a plasma-cell dyscrasia, with systemic amyloidosis of five years' duration. Because of the remote likelihood of chance association of acute leukemia and multiple myeloma, the known effect of alkylating agents on deoxyribonucleic acid, the fact that the leukemia was myelomonocytic, and the long period of treatment with melphalan, a possible etiologic role of melphalan therapy in the development of acute leukemia is suggested.
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Cites
Bizzozero, O. J., Johnson, K. G., Ciocco, A., Hoshino, T., Itoga, T., Toyoda, S., & Kawasaki, S. (1966) · New England Journal of Medicine · doi:10.1056/nejm196605192742001 · Cited by 200
Stem Cell Leukaemia in Myelomatosis
Andersen, E., & VIDEBAEK, A. (1970) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1970.tb01888.x · Cited by 80
Cited by
Lenalidomide after Stem-Cell Transplantation for Multiple Myeloma
McCarthy, P. L., Owzar, K., Hofmeister, C. C., Hurd, D. D., Hassoun, H., Richardson, P. G., Giralt, S., Stadtmauer, E. A., Weisdorf, D. J., Vij, R., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114083 · Cited by 1,147
Acute Leukemia after Alkylating-Agent Therapy of Ovarian Cancer
Reimer, R. R., Hoover, R., Fraumeni, J. F., & Young, R. C. (1977) · New England Journal of Medicine · doi:10.1056/nejm197707282970402 · Cited by 448
Historical review of the causes of cancer
Blackadar, C. B. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i1.54 · Cited by 389
(1976) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60176-1 · Cited by 274
Metadata
- Authors
- Kyle, R. A., Pierre, R. V., & Bayrd, E. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1970-11-19
- Volume
- 283
- Issue
- 21
- Pages
- 1121-1125
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337897057
- Cited by
- 283
- References
- 2
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multiple Myeloma and Acute Myelomonocytic Leukemia: Report of Four Cases Possibly Related to Melphalan. https://app.cochat.ai/papers/10.1056/nejm197011192832101
- The paper
- Kyle, R. A., Pierre, R. V., & Bayrd, E. D. (1970). Multiple Myeloma and Acute Myelomonocytic Leukemia: Report of Four Cases Possibly Related to Melphalan. New England Journal of Medicine. https://doi.org/10.1056/nejm197011192832101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
