The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Acute Leukemia after Alkylating-Agent Therapy of Ovarian Cancer
Abstract
To estimate the leukemogenic potential of alkylating agents, we surveyed 70 institutions using these drugs for the frequency of second cancers in patients with advanced ovarian cancer. Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0.62 cases expected (relative risk = 21.0). All 13 had received alkylating agents. Nine also received radiotherapy. The relative risk for patients given chemotherapy was 36.1 and rose to 171.4 for those surviving for two years (rate = 13.75 per 1000 patients per year). To evaluate the role of therapy versus underlying disease, a historical control of 13,309 patients with ovarian cancer in the National Cancer Institute's End Results Program was analyzed. No excess of leukemia was noted in this group, even among 6596 women receiving radiation. The excess of acute nonlymphocytic leukemia, therefore, appears attribute to alkylating agents, although the effect may be enhanced by exposure to radiation, as previously suggested for Hodgkin's disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
RISK OF CANCER IN RENAL-TRANSPLANT RECIPIENTS
Hoover, R. N., & Fraumeni, J. (1973) · The Lancet · doi:10.1016/s0140-6736(73)93256-x · Cited by 596
Self-citationKyle, R. A., Pierre, R. V., & Bayrd, E. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197011192832101 · Cited by 283
Schroeder, T. M., & KURTH, R. (1971) · Blood · doi:10.1182/blood.v37.1.96.96 · Cited by 131
Cited by
Rowley, J., Golomb, H., & Vardiman, J. (1981) · Blood · doi:10.1182/blood.v58.4.759.759 · Cited by 441
Historical review of the causes of cancer
Blackadar, C. B. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i1.54 · Cited by 389
Cancer of the Breast: The Past Decade
Henderson, I. C., & Canellos, G. P. (1980) · New England Journal of Medicine · doi:10.1056/nejm198001103020203 · Cited by 257
Randomized trial of chlorambucil for primary biliary cirrhosis
Hoofnagle, J. H., Davis, G. L., Schafer, D. F., Peters, M., Avigan, M. I., Pappas, S. C., Hanson, R. G., Minuk, G. Y., Dusheiko, G. M., Campbell, G., et al. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90183-6 · Cited by 157
Metadata
- Authors
- Reimer, R. R., Hoover, R., Fraumeni, J. F., & Young, R. C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-07-28
- Volume
- 297
- Issue
- 4
- Pages
- 177-181
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336358779
- Cited by
- 448
- References
- 3
- FWCI
- 45.82
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Acute Leukemia after Alkylating-Agent Therapy of Ovarian Cancer. https://app.cochat.ai/papers/10.1056/nejm197707282970402
- The paper
- Reimer, R. R., Hoover, R., Fraumeni, J. F., & Young, R. C. (1977). Acute Leukemia after Alkylating-Agent Therapy of Ovarian Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejm197707282970402
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
