The DOI matches its Crossref record.
Incidence and Meaning of Persistence of Australia Antigen in Patients with Acute Viral Hepatitis: Development of Chronic Hepatitis
Abstract
Abstract In a prospective study for occurrence and persistence of Australia antigen, 253 consecutively admitted patients with biopsy-verified acute viral hepatitis were examined. Australia antigen was detected in serum specimens from 112 of the patients (44 per cent). In 88 of these 112, the antigen was transitorily detectable for one to 13 weeks (average, 4 1/2 weeks). Australia antigen persisted for more than 13 weeks in 11 of the 253 patients (4.3 per cent), in all of whom clinical and biochemical signs of chronic hepatitis developed. In 10 of these patients the chronic hepatitis was verified by repeated liver biopsies. Chronic aggressive hepatitis developed in eight patients, and chronic persistent hepatitis in two. Thus, 4 to 5 per cent of the patients with acute viral hepatitis admitted to Copenhagen hospitals have persistence of Australia antigen for several months; in this group, chronic hepatitis is apt to develop.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
McMahon, B. J., Alward, W. L. M., Hall, D. B., Heyward, W. L., Bender, T. R., Francis, D. P., & Maynard, J. E. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/151.4.599 · Cited by 832
Risks of chronicity following acute hepatitis B virus infection: a review.
Hyams, K. C. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.4.992 · Cited by 521
Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults
Tassopoulos, N. C., Papaevangelou, G. J., Sjogren, M. H., Roumeliotou-karayannis, A., Gerin, J. L., & Purcell, R. H. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90614-7 · Cited by 271
Metadata
- Authors
- Nielsen, J. O., Dietrichson, O., Elling, P., Christoffersen, P., Faber, V., Iversen, K., Juhl, E., Petersen, P., & Poulsen, H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-11-18
- Volume
- 285
- Issue
- 21
- Pages
- 1157-1160
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1971256169
- Cited by
- 187
- References
- 0
- FWCI
- 38.93
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Incidence and Meaning of Persistence of Australia Antigen in Patients with Acute Viral Hepatitis: Development of Chronic Hepatitis. https://app.cochat.ai/papers/10.1056/nejm197111182852101
- The paper
- Nielsen, J. O., Dietrichson, O., Elling, P., Christoffersen, P., Faber, V., Iversen, K., Juhl, E., Petersen, P., & Poulsen, H. (1971). Incidence and Meaning of Persistence of Australia Antigen in Patients with Acute Viral Hepatitis: Development of Chronic Hepatitis. New England Journal of Medicine. https://doi.org/10.1056/nejm197111182852101
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
