The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Propranolol Inhibition of Renin Secretion: A Specific Approach to Diagnosis and Treatment of Renin-Dependent Hypertensive Diseases
Abstract
The antihypertensive effect and mechanism of propranolol were studied in 47 hypertensive patients classified according to high, normal, or low plasma renin activity. The drug was uniformly effective in 13 patients with high renin activity and malignant, renovascular, or essential hypertension, producing a mean fall in diastolic pressure of 30 mm of mercury. In 22 with normal renin, propranolol reduced mean diastolic pressure by 20 mm of mercury, but individual responses were less consistent. In contrast, the drug was uniformly ineffective in the 12 patients with low-renin essential hypertension. In all three groups, the action of propranolol closely correlated with both the control renin levels and the degree of renin suppression produced. Propranolol usually suppressed aldosterone secretion but to a lesser extent than it did renin, perhaps because of a hyperkalemic effect of the drug. These special effects of propranolol in renin-dependent hypertensions point to the possibility of an associated neurogenic mechanism in these patients.
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Citations
Cites
Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke
Brunner, H. R., Laragh, J. H., Baer, L., Newton, M. A., Goodwin, F. T., Krakoff, L. R., Bard, R. H., & Bühler, F. R. (1972) · New England Journal of Medicine · doi:10.1056/nejm197203022860901 · Cited by 1,093
Self-citationLaragh, J. H., Baer, L., Brunner, H. R., Buhler, F. R., & Vaughan, J. E. (1972) · The American Journal of Medicine · doi:10.1016/0002-9343(72)90054-x · Cited by 543
Self-citationThe renin system: Variations in man measured by radioimmunoassay or bioassay
Sealey, J. E., Gerten-Banes, J., & Laragh, J. H. (1972) · Kidney International · doi:10.1038/ki.1972.34 · Cited by 382
Self-citationRole of Parasympathetic Inhibition in the Hyperkinetic Type of Borderline Hypertension
JULIUS, S., PASCUAL, A. V., & LONDON, R. (1971) · Circulation · doi:10.1161/01.cir.44.3.413 · Cited by 335
Adrenergic Receptor Mediation of Renin Secretion
WINER, N., CHOKSHI, D. S., YOON, M. S., & FREEDMAN, A. D. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-9-1168 · Cited by 241
Brunner, H. R., Baer, L., Sealey, J. E., Ledingham, J. G. G., & Laragh, J. H. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106430 · Cited by 219
Self-citationGOTTLIEB, T. B., KATZ, F. H., & CHIDSEY, C. A. (1972) · Circulation · doi:10.1161/01.cir.45.3.571 · Cited by 204
Hyperdynamic Beta-Adrenergic Circulatory State
Frohlich, E. D. (1966) · Archives of Internal Medicine · doi:10.1001/archinte.117.5.614 · Cited by 178
Hypertension and Low Plasma Renin Activity: Presumptive Evidence for Mineralocorticoid Excess
Spark, R. F., & Melby, J. C. (1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-6-831 · Cited by 165
Potassium balance and the control of renin secretion
Sealey, J. E., Clark, I., Bull, M. B., & Laragh, J. H. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106429 · Cited by 163
Self-citation
Cited by
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642
Staessen, J. A., Li, Y., & Richart, T. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69442-7 · Cited by 284
Low-renin status in therapy-resistant hypertension: a clue to efficient treatment
Eide, I. K., Torjesen, P. A., Drolsum, A., Babovic, A., & Lilledahl, N. P. (2004) · Journal of Hypertension · doi:10.1097/00004872-200411000-00026 · Cited by 265
Fu, Q., VanGundy, T. B., Shibata, S., Auchus, R. J., Williams, G. H., & Levine, B. D. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.172262 · Cited by 175
Esler, M., Lambert, E., & Schlaich, M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00182.2010 · Cited by 141
Metadata
- Authors
- Bühler, F. R., Laragh, J. H., Baer, L., Vaughan, E. D., & Brunner, H. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1972-12-14
- Volume
- 287
- Issue
- 24
- Pages
- 1209-1214
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1997388963
- Cited by
- 718
- References
- 15
- FWCI
- 70.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Propranolol Inhibition of Renin Secretion: A Specific Approach to Diagnosis and Treatment of Renin-Dependent Hypertensive Diseases. https://app.cochat.ai/papers/10.1056/nejm197212142872401
- The paper
- Bühler, F. R., Laragh, J. H., Baer, L., Vaughan, E. D., & Brunner, H. R. (1972). Propranolol Inhibition of Renin Secretion: A Specific Approach to Diagnosis and Treatment of Renin-Dependent Hypertensive Diseases. New England Journal of Medicine. https://doi.org/10.1056/nejm197212142872401
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
