Role of Parasympathetic Inhibition in the Hyperkinetic Type of Borderline Hypertension

Abstract

Eleven patients with borderline hypertension and high cardiac output were compared to 16 paid healthy volunteers. Cardiac output, heart rate, and intraarterial blood pressure were determined at rest, after administration of 0.2 mg/kg of propranolol i.v., and after administration of an additional 0.04 mg/kg of atropine. In four additional patients, response to infusion of isoproterenol before and after administration of 0.2 mg/kg of propranolol i.v. was evaluated. Resting heart rate and cardiac output in patients with borderline hypertension were elevated. After propranolol infusion, the values decreased more in the patients with borderline hypertension, but remained significantly elevated. After atropine administration, the difference in cardiac output and heart rate between the two groups disappeared. Consequently, patients with borderline hypertension and hyperkinetic circulation simultaneously exhibit an increase of sympathetic and a decrease of parasympathetic tone.