Point: Chronic Activation of the Sympathetic Nervous System is the Dominant Contributor to Systemic Hypertension

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works

Neural control of renal function

DiBona, G. F., & Kopp, U. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.1.75 · Cited by 1,212 · see citing works

Sympathetic Overactivity in Patients with Chronic Renal Failure

Converse, R. L., Jacobsen, T. N., Toto, R. D., Jost, C. M. T., Cosentino, F., Fouad-Tarazi, F., & Victor, R. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272704 · Cited by 1,132 · see citing works

Neural Control of Renal Function*

Kopp, U. C., & DiBona, G. F. (2020) · Reflex Control of the Circulation · doi:10.1201/9780367813338-17 · Cited by 1,126 · see citing works

Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension

Schlaich, M. P., Sobotka, P. A., Krum, H., Lambert, E., & Esler, M. D. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0904179 · Cited by 772 · see citing works

Propranolol Inhibition of Renin Secretion

Bühler, F. R., Laragh, J. H., Baer, L., Vaughan, E. D., & Brunner, H. R. (1972) · New England Journal of Medicine · doi:10.1056/nejm197212142872401 · Cited by 718 · see citing works

Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover.

Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642 · see citing works

Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings.

Anderson, E. A., Sinkey, C. A., Lawton, W. J., & Mark, A. L. (1989) · Hypertension · doi:10.1161/01.hyp.14.2.177 · Cited by 632 · see citing works

Sympathetic Augmentation in Hypertension

Schlaich, M. P., Lambert, É., Kaye, D. M., Krozowski, Z. S., Campbell, D. J., Lambert, G. W., Hastings, J., Aggarwal, A., & Esler, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000103160.35395.9e · Cited by 509 · see citing works

Sympathetic Nerve Activity in End-Stage Renal Disease

Hausberg, M., Kosch, M., Harmelink, P., Barenbrock, M., Hohage, H., Kisters, K., Dietl, K. H., & Rahn, K. H. (2002) · Circulation · doi:10.1161/01.cir.0000034043.16664.96 · Cited by 493 · see citing works

Mechanisms of Sympathetic Activation in Obesity-Related Hypertension

Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443 · see citing works

Sympathetic Activation in Chronic Renal Failure

Schlaich, M. P., Socratous, F., Hennebry, S., Eikelis, N., Lambert, E. A., Straznicky, N., Esler, M. D., & Lambert, G. W. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008040402 · Cited by 408 · see citing works

Neural mechanisms in human obesity-related hypertension

Rumantir, M. S., Vaz, M., Jennings, G. L., Collier, G., Kaye, D. M., Seals, D. R., Wiesner, G. H., Brunner-La Rocca, H. P., & Esler, M. D. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917080-00012 · Cited by 396 · see citing works

Renal Afferent Denervation Prevents Hypertension in Rats With Chronic Renal Failure

Campese, V. M., & Kogosov, E. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.878 · Cited by 356 · see citing works

Resolved and unresolved issues in the prevention and treatment of coronary artery disease: A workshop consensus statement

Dzau, V. J., & D, E. B. M. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90694-d · Cited by 324 · see citing works

Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome

Grassi, G., Dell’Oro, R., Quarti-Trevano, F., Scopelliti, F., Seravalle, G., Paleari, F., Gamba, P. L., & Mancia, G. (2005) · Diabetologia · doi:10.1007/s00125-005-1798-z · Cited by 294 · see citing works

Dissociation Between Muscle and Skin Sympathetic Nerve Activity in Essential Hypertension, Obesity, and Congestive Heart Failure

Grassi, G., Colombo, M., Seravalle, G., Spaziani, D., & Mancia, G. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.64 · Cited by 256 · see citing works

Age-related changes in muscle sympathetic nerve activity in essential hypertension

Yamada, Y., Miyajima, E., Tochikubo, O., Matsukawa, T., & Ishii, M. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.870 · Cited by 220 · see citing works

The blind men and the elephant

Go, K., & Carroll, J. M. (2004) · interactions · doi:10.1145/1029036.1029037 · Cited by 213 · see citing works

Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension

Huggett, R. J., Burns, J., Mackintosh, A. F., & Mary, D. A. S. G. (2004) · Hypertension · doi:10.1161/01.hyp.0000147893.08533.d8 · Cited by 211 · see citing works

Differing Pattern of Sympathoexcitation in Normal-Weight and Obesity-Related Hypertension

Lambert, E., Straznicky, N., Schlaich, M., Esler, M., Dawood, T., Hotchkin, E., & Lambert, G. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.094649 · Cited by 195 · see citing works

Regional Norepinephrine Turnover in Human Hypertension

Esler, M., Lambert, G., & Jennings, G. (1989) · Clinical and Experimental Hypertension. Part A: Theory and Practice · doi:10.3109/10641968909045414 · Cited by 161 · see citing works

Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat.

Judy, W. V., Watanabe, A. M., Murphy, W. R. C., Aprison, B. S., & Yu, P. (1979) · Hypertension · doi:10.1161/01.hyp.1.6.598 · Cited by 143 · see citing works

Chronic Management of Blood Pressure After Stroke

Pedelty, L., & Gorelick, P. B. (2004) · Hypertension · doi:10.1161/01.hyp.0000129170.50448.5f · Cited by 122 · see citing works

Management of Uncontrollable Hypertension With a Carotid Sinus Stimulation Device

Mohaupt, M. G., Schmidli, J., & Luft, F. C. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.099416 · Cited by 68 · see citing works

Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: Reduction by a selective serotonin reuptake inhibitor

Esler, M., Lambert, É., Alvarenga, M. E., Socratous, F., Richards, J., Esler, M., Lambert, É., Alvarenga, M. E., Socratous, F., Richards, J., et al. (2007) · Stress · doi:10.1080/10253890701300904 · Cited by 50 · see citing works

HYPERTENSION AND ASSOCIATED CARDIOVASCULAR DISEASE

Smithwick, R. H. (1956) · JAMA · doi:10.1001/jama.1956.02960470019005 · Cited by 41 · see citing works

Efferent Renal Nerve Traffic in the Spontaneously Hypertensive Rat

Thorén, P. (1987) · Clinical and Experimental Hypertension · doi:10.3109/10641968709160178 · Cited by 28 · see citing works

Amlodipine Better Than Lisinopril?

Messerli, F. H., & Staessen, J. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000238045.76905.94 · Cited by 19 · see citing works

Clinical Trials for Hypertension

Kaplan, N. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000253034.35704.92 · Cited by 14 · see citing works

Truncated Prorenin Comes Up … Short

Reudelhuber, T. L. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.140392 · Cited by 5 · see citing works

The Sympathetic Nervous System Alterations in Human Hypertension

Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works

Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series

Brinkmann, J., Heusser, K., Schmidt, B. M., Menne, J., Klein, G., Bauersachs, J., Haller, H., Sweep, F. C., Diedrich, A., Jordan, J., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201186 · Cited by 166 · see citing works

The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation

Nishi, E. E., Bergamaschi, C. T., & Campos, R. R. (2015) · Experimental Physiology · doi:10.1113/expphysiol.2014.079889 · Cited by 73 · see citing works

Renal sympathetic activity: A key modulator of pressure natriuresis in hypertension

Díaz-Morales, N., Baranda-Alonso, E. M., Martínez-Salgado, C., & López-Hernández, F. J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115386 · Cited by 24 · see citing works

Tautology vs. Physiology in the Etiology of Hypertension

Beard, D. A. (2013) · Physiology · doi:10.1152/physiol.00038.2013 · Cited by 21 · see citing works

Low dose of moxonidine within the rostral ventrolateral medulla improves the baroreflex sensitivity control of sympathetic activity in hypertensive rat

Wang, J., Wang, L., Wu, Z.-T., Yuan, W., Su, D., Ni, X., Yan, J.-J., & Wang, W. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.165 · Cited by 9 · see citing works

Abstract 14355: Inhibition of ROS in the Rostral Ventrolateral Medulla Improves Baroreflex Function in Stroke-Prone Spontaneously Hypertensive Rats

Ogawa, K., Hirooka, Y., Kishi, T., et al. (2011) · Circulation

The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart

Ang, R. J., Birnbaumer, L., Gourine, A. V., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht310.p5030

Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A

Xu, Y., & Krukoff, T. L. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706698 · Cited by 18 · see citing works

Analysis of Human Autonomic Nervous Activity Based on Big Data Measurement via SmartPhone

Komazawa, M., Itao, K., Kobayashi, H., et al. (2016) · IEEE International Conference on Dependable, Autonomic and Secure Computing, International Conference on Pervasive Intelligence and Computing, International Conference on Big Data Intelligence and Computing and Cyber Science and Technology Congress (DASC/PiCom/DataCom/CyberSciTech) · doi:10.1109/dasc-picom-datacom-cyberscitec.2016.144