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Cited by 390

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Anorexia Nervosa: Immaturity of the 24-Hour Luteinizing Hormone Secretory Pattern

Boyar, R. M., Katz, J., Finkelstein, J.W., Kapen, S., Weiner, H., Weitzman, E.D., Hellman, Leon·1974·New England Journal of Medicine

Abstract

Nine women (17 to 23 years of age) with primary anorexia nervosa associated with amenorrhea had measurements of plasma luteinizing hormone concentrations at 20-minute intervals for 24 hours. Eight of the nine showed age-inappropriate secretory patterns that resembled those found in prepubertal and pubertal children. The finding of an "immature" luteinizing hormone pattern suggests that a "regression" (in the patients with secondary amenorrhea) or an "arrest" (in the patients with primary amenorrhea) of the luteinizing hormone secretory "program" occurs in this disorder. One patient had a spontaneous remission, with return of body weight to normal, associated with a maturational change from the early pubertal luteinizing hormone pattern found during her illness to one characteristic of postmenarchal girls, indicating the reversibility of this abnormality. The finding of a relation between body weight and the maturity of the luteinizing hormone pattern supports the hypothesis that a "critical body weight" is an important factor in the initiation of menarche. (N Engl J Med 291: 861 -865, 1974)

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Crossref · 10.1056/nejm197410242911701

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Metadata

Authors
Boyar, R. M., Katz, J., Finkelstein, J. W., Kapen, S., Weiner, H., Weitzman, E. D., & Hellman, L.
Venue
New England Journal of Medicine
Published
1974-10-24
Volume
291
Issue
17
Pages
861-865
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2039882532
Cited by
390
References
1
FWCI
13.11
Type
journal article
Language
en
Open access
closed

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