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Transfusion-Associated Hepatitis Not Due to Viral Hepatitis Type A or B
Abstract
Twenty-two patients who had an episode of transfusion-associated hepatitis not positive for hepatitis B antigen were examined for development of antibody to heaptitis A and B antigens, cytomegalovirus and Epstein-Barr virus. Antibody response to the 27-nm virus-like hepatitis A antigen was measured by immune electron microscopy. In none of the 22 patients studied did serologic evidence of infection with hepatitis A virus develop during the study period. Nine of the 22 patients had antibody responses to cytomegalovirus, but it was difficult to relate these seroconversions to their hepatitis. In addition, all 22 patients had pre-existing antibody to the Epstein-Barr virus. It seems likely that at least a proportion of such antigen-negative transfusion-associated hepatitis is caused by other infectious agents, not yet identified.
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Citations
Cited by
An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis
Kuo, G., Choo, Q.-L., Alter, H. J., Gitnick, G. L., Redeker, A. G., Purcell, R. H., Miyamura, T., Dienstag, J. L., Alter, M. J., Stevens, C. E., et al. (1989) · Science · doi:10.1126/science.2496467 · Cited by 3,346
Self-citationHEPATITIS C VIRUS ANTIBODIES AMONG RISK GROUPS IN SPAIN
Esteban, J. I., Viladomiu, L., Gonzalez, A., Roget, M., Genescà, J., Esteban, R., López-Talavera, J. C., Hernández, J. M., Vargas, V., Buti, M., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90485-6 · Cited by 886
Isolation of a cDNA from the Virus Responsible for Enterically Transmitted Non-A, Non-B Hepatitis
Reyes, G. R., Purdy, M. A., Kim, J., Luk, K.-C., Young, L. M., Fry, K. E., & Bradley, D. W. (1990) · Science · doi:10.1126/science.2107574 · Cited by 867
GARSON, J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91446-h · Cited by 558
Hepatitis C virus infection in USA: an estimate of true prevalence
Chak, E., Talal, A. H., Sherman, K. E., Schiff, E. R., & Saab, S. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02494.x · Cited by 396
Metadata
- Authors
- Feinstone, S. M., Kapikian, A. Z., Purcell, R. H., Alter, H. J., & Holland, P. V.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1975-04-10
- Volume
- 292
- Issue
- 15
- Pages
- 767-770
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3025122695
- Cited by
- 690
- References
- 0
- FWCI
- 25.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transfusion-Associated Hepatitis Not Due to Viral Hepatitis Type A or B. https://app.cochat.ai/papers/10.1056/nejm197504102921502
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- Feinstone, S. M., Kapikian, A. Z., Purcell, R. H., Alter, H. J., & Holland, P. V. (1975). Transfusion-Associated Hepatitis Not Due to Viral Hepatitis Type A or B. New England Journal of Medicine. https://doi.org/10.1056/nejm197504102921502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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