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The Dialysis Encephalopathy Syndrome: Possible Aluminum Intoxication
Abstract
The aluminum content of muscle, bone and brain was measured in control subjects and in uremic patients on dialysis who had been maintained on phosphate-binding aluminum gels. The mean muscle aluminum was 14.8 ppm, and the trabecular-bone aluminum 98.5 ppm in the patients on dialysis, as compared with 1.2 and 2.4 in control subjects (P less than 0.05). Brain gray-matter aluminum values in a group of uremic patients on dialysis who died of a neurologic syndrome of unknown cause were 25 ppm as compared with 6.5 ppm in a group of uremic patients on dialysis who died of other causes and 2.2 ppm in control subjects. The fact that brain gray-matter aluminum was higher in all patients with the dialysis-associated encephalopathy syndrome than any of the control subjects or other uremic patients on dialysis suggests that this syndrome may be due to aluminum in intoxication.
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Citations
Cited by
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Kawahara, M., & Kato-Negishi, M. (2011) · International Journal of Alzheimer’s Disease · doi:10.4061/2011/276393 · Cited by 509
Exley, C. (2013) · Environ. Sci.: Processes Impacts · doi:10.1039/c3em00374d · Cited by 382
Alzheimer's disease, metal ions and metal homeostatic therapy
Zatta, P., Drago, D., Bolognin, S., & Sensi, S. L. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.05.002 · Cited by 369
Becaria, A., Campbell, A., & Bondy, S. (2002) · Toxicology and Industrial Health · doi:10.1191/0748233702th157oa · Cited by 283
Metadata
- Authors
- Alfrey, A. C., LeGendre, G. R., & Kaehny, W. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-01-22
- Volume
- 294
- Issue
- 4
- Pages
- 184-188
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2062571325
- Cited by
- 1,621
- References
- 0
- FWCI
- 69.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alfrey, A. C., LeGendre, G. R., & Kaehny, W. D. (1976). The Dialysis Encephalopathy Syndrome: Possible Aluminum Intoxication. New England Journal of Medicine. https://doi.org/10.1056/nejm197601222940402
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