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Cited by 389Aluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and ToxicityEnvironmental Toxicology and Ecotoxicology

Human exposure to aluminium

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Exley, Christopher·2013·Environ. Sci.: Processes Impacts
DOI 10.1039/c3em00374d
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Abstract

Human activities have circumvented the efficient geochemical cycling of aluminium within the lithosphere and therewith opened a door, which was previously only ajar, onto the biotic cycle to instigate and promote the accumulation of aluminium in biota and especially humans. Neither these relatively recent activities nor the entry of aluminium into the living cycle are showing any signs of abating and it is thus now imperative that we understand as fully as possible how humans are exposed to aluminium and the future consequences of a burgeoning exposure and body burden. The aluminium age is upon us and there is now an urgent need to understand how to live safely and effectively with aluminium.

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  • Aluminium can be a metallic toxicant to humans and animals when there is a high body burden of the metal after natural or unnatural exposure.

    “The Al ion has no physiological role in metabolic processes (Exley and House, 2011) but it can be a metallic toxicant to humans and animals (Becaria et al., 2002) when there is high body burden of the metal after natural or unnatural exposure (Exley, 2013).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Exley, 2013

    In “The body burden of aluminium,” the paper describes body burden as the outcome of exposure and excretion and says a higher-than-normal burden is assumed to increase susceptibility to aluminium. But it cautions that body burden may not accurately predict toxicity; the Conclusions instead emphasize biologically available aluminium. The claim’s high-burden condition is therefore stronger than the source supports. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Toxic effects of aluminium arise mainly from its pro-oxidant activity, which results in oxidative stress, free radical attack and oxidation of cellular proteins and lipids.

    “Toxic effects of Al arise mainly from its pro-oxidant activity which results in oxidative stress, free radical attack and oxidation of cellular proteins and lipids (Exley, 2013).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Exley, 2013

    The Pro-oxidant section calls aluminium a potent pro-oxidant and says its activity may be significant at concentrations commonly found in the body. It does not establish that this is the main cause of aluminium toxicity or state that it results in oxidative stress, free-radical attack, and oxidation of cellular proteins and lipids. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Exley, C.
Affiliations
Keele University (GB)
Corresponding author
Exley, Christopher
ORCID
Exley, Christopher
Venue
Environ. Sci.: Processes Impacts
Publisher
Royal Society of Chemistry (RSC)
Published
2013
Volume
15
Issue
10
Pages
1807-1816
ISSN
  • 2050-7887 (ISSN-L)
  • 2050-7895
DOI
10.1039/c3em00374d
OpenAlex
W2098844459
Cited by
382
References
93
Citations by year
2026: 30 · 2025: 25 · 2024: 38 · 2023: 34 · 2022: 28 · 2021: 43 · 2020: 41 · 2019: 37 · 2018: 24 · 2017: 17 · 2016: 21 · 2015: 15 · 2014: 25 · 2013: 3
FWCI
2.29
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Environmental Science Processes & Impacts (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords
aluminum exposure, human body burden, environmental contamination
MeSH terms
Aluminum, Body Burden, Environmental Exposure, Environmental Pollutants, Humans

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