The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study.
Abstract
One hundred fifty patients with potentially life-threatening digitalis toxicity were treated with digoxin-specific antibody fragments (Fab) purified from immunoglobulin G produced in sheep. The dose of Fab fragments was equal to the amount of digoxin or digitoxin in the patient's body as estimated from medical histories or determinations of serum digoxin or digitoxin concentrations. The youngest patient received Fab fragments within several hours of birth, and the oldest patient was 94 years old. Seventy-five patients (50%) were receiving long-term digitalis therapy, 15 (10%) had taken a large overdose of digitalis accidentally, and 59 (39%) had ingested an overdose of digitalis with suicidal intent. The clinical response to Fab was unspecified in two cases, leaving 148 patients who could be evaluated. One hundred nineteen patients (80%) had resolution of all signs and symptoms of digitalis toxicity, 14 (10%) improved, and 15 (10%) showed no response. After termination of the Fab infusion, the median time to initial response was 19 minutes, and 75% of the patients had some evidence of a response by 60 minutes. There were only 14 patients with adverse events considered to possibly or probably have been caused by Fab; the most common events were rapid development of hypokalemia and exacerbation of congestive heart failure. No allergic reactions were identified in response to Fab treatment. Of patients who experienced cardiac arrest as a manifestation of digitalis toxicity, 54% survived hospitalization.(ABSTRACT TRUNCATED AT 250 WORDS)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Replacing the complementarity-determining regions in a human antibody with those from a mouse
Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. (1986) · Nature · doi:10.1038/321522a0 · Cited by 1,406
Determination of Therapeutic and Toxic Serum Digoxin Concentrations by Radioimmunoassay
Smith, T. W., Butler, V. P., & Haber, E. (1969) · New England Journal of Medicine · doi:10.1056/nejm196911272812203 · Cited by 583
Self-citationCosimi, A. B., Colvin, R. B., Burton, R. C., Rubin, R. H., Goldstein, G., Kung, P. C., Hansen, W. P., Delmonico, F. L., & Russell, P. S. (1981) · New England Journal of Medicine · doi:10.1056/nejm198108063050603 · Cited by 505
Reversal of Advanced Digoxin Intoxication with Fab Fragments of Digoxin-Specific Antibodies
Smith, T. W., Haber, E., Yeatman, L., & Butler, V. P. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604082941501 · Cited by 377
Self-citationDigitalis: Mechanisms of Action and Clinical Use
Epstein, F. H., & Smith, T. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802113180606 · Cited by 346
Self-citationSmith, T. W., Butler, V. P., Haber, E., Fozzard, H., Marcus, F. I., Bremner, W. F., Schulman, I. C., & Phillips, A. (1982) · New England Journal of Medicine · doi:10.1056/nejm198211253072201 · Cited by 296
Self-citationCharacterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin
Smith, T. W., Butler, V. P., & Haber, E. (1970) · Biochemistry · doi:10.1021/bi00804a020 · Cited by 234
Self-citationTreatment of 63 severely digitalis-toxic patients with digoxin-specific antibody fragments
Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W. (1985) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(85)80471-x · Cited by 173
Self-citation
Cited by
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Panchal, A. R., Bartos, J. A., Cabañas, J. G., Donnino, M. W., Drennan, I. R., Hirsch, K. G., Kudenchuk, P. J., Kurz, M. C., Lavonas, E. J., Morley, P. T., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000916 · Cited by 2,105
Topjian, A. A., Raymond, T. T., Atkins, D., Chan, M., Duff, J. P., Joyner, B. L., Lasa, J. J., Lavonas, E. J., Levy, A., Mahgoub, M., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000901 · Cited by 1,258
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178233 · Cited by 1,080
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.044 · Cited by 1,008
Metadata
- Authors
- Antman, E. M., Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W.
- Venue
- Circulation
- Published
- 1990-06
- Volume
- 81
- Issue
- 6
- Pages
- 1744-1752
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1996877405
- Cited by
- 393
- References
- 8
- FWCI
- 29.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. https://app.cochat.ai/papers/10.1161/01.cir.81.6.1744
- The paper
- Antman, E. M., Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W. (1990). Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. Circulation. https://doi.org/10.1161/01.cir.81.6.1744
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
