Cited by 352Antibiotic Use and ResistanceAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental Impacts

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Changes in Intestinal Flora of Farm Personnel after Introduction of a Tetracycline-Supplemented Feed on a Farm

Levy, Stuart B., FitzGerald, George B., Macone, Ann B.·1976·New England Journal of Medicine

DOI 10.1056/nejm197609092951103

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Abstract

A prospective study was undertaken to determine whether feeding farm animals antibiotics in feed caused changes in the intestinal bacterial flora of farm dwellers and their neighbors. Chickens were fed tetracycline-supplemented feed (tet-feed), and, as expected, within one week their intestinal flora contained almost entirely tetracycline-resistant organisms. Increased numbers of resistant intestinal bacteria also appeared, but more slowly, in farm members, but not their neighbors. Within five and six months, 31.3 per cent of weekly fecal samples from farm dwellers contained greater than 80 per cent tetracycline-resistant bacteria as compared to 6.8 per cent of the samples from the neighbors (P less than 0.001). Seven of the 11 farm members, but only three of the 24 neighbors, had two or more fecal samples containing greater than 80 per cent tetracycline-resistant coliforms (P less than 0.01). These resistant bacteria contained transferable plasmids conferring multiple antibiotic resistances. Selective pressure by tet-feed for antibiotic-resistant bacteria in chickens extends to human beings in contact with chickens and the feed.

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Self-citation
Human pathogens and tetracycline-resistant bacteria in bioaerosols of swine confinement buildings and in nasal flora of hog producers
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Authors: Levy, S. B., FitzGerald, G. B., & Macone, A. B.
Affiliations: Tufts University (US)
ORCID: Levy, Stuart B.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1976-09-09
Volume: 295
Issue: 11
Pages: 583-588
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm197609092951103
OpenAlex: W2325966728
Cited by: 352
References: 23
Citations by year: 2025: 7 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 14 · 2019: 8 · 2018: 10 · 2017: 15 · 2016: 19 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 8
FWCI: 26.97
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords: tetracycline resistance, antibiotic resistance, intestinal bacterial flora, farm workers, poultry feed, chickens, coliform bacteria, plasmid-mediated resistance, selection pressure
MeSH terms: Adolescent, Adult, Agriculture, Animals, Animal Feed, Animals, Domestic, Bacteria, Chickens, Child, Child, Preschool, Drug Resistance, Microbial, Eggs, Feces, Female, Food Microbiology, Humans, Intestines, Male, Occupations, R Factors, Tetracyclines

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Changes in Intestinal Flora of Farm Personnel after Introduction of a Tetracycline-Supplemented Feed on a Farm

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