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Legionnaires' Disease: Description of an Epidemic of Pneumonia
Abstract
An explosive, common-source outbreak of pneumonia caused by a previously unrecognized bacterium affected primarily persons attending an American Legion convention in Philadelphia in July, 1976. Twenty-nine of 182 cases were fatal. Spread of the bacterium appeared to be air borne. The source of the bacterium was not found, but epidemiologic analysis suggested that exposure may have occurred in the lobby of the headquarters hotel or in the area immediately surrounding the hotel. Person-to-person spread seemed not to have occurred. Many hotel employees appeared to be immune, suggesting that the agent may have been present in the vicinity, perhaps intermittently, for two or more years.
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Citations
Cited by
Horwitz, M. A., & Silverstein, S. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109874 · Cited by 639
Current and Emerging Legionella Diagnostics for Laboratory and Outbreak Investigations
Mercante, J. W., & Winchell, J. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-14 · Cited by 339
Adverse Health Effects Among Adults Exposed to Home Dampness and Molds
Dales, R. E., Burnett, R., & Zwanenburg, H. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.3.505 · Cited by 295
Reflections on the 1976 swine flu vaccination program
Sencer, D. J., & Millar, J. D. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.051007 · Cited by 163
Dictyostelium transcriptional host cell response upon infection with Legionella
Farbrother, P., Wagner, C., Na, J., Tunggal, B., Morio, T., Urushihara, H., Tanaka, Y., Schleicher, M., Steinert, M., & Eichinger, L. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00633.x · Cited by 112
Metadata
- Authors
- Fraser, D. W., Tsai, T. R., Orenstein, W., Parkin, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., McDade, J. E., Shepard, C. C., Brachman, P. S., & the Field Investigation Team*
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-12
- Volume
- 297
- Issue
- 22
- Pages
- 1189-1197
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1971857640
- Cited by
- 1,713
- References
- 0
- FWCI
- 39.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Legionnaires' Disease: Description of an Epidemic of Pneumonia. https://app.cochat.ai/papers/10.1056/nejm197712012972201
- The paper
- Fraser, D. W., Tsai, T. R., Orenstein, W., Parkin, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., McDade, J. E., Shepard, C. C., Brachman, P. S., & the Field Investigation Team*. (1977). Legionnaires' Disease: Description of an Epidemic of Pneumonia. New England Journal of Medicine. https://doi.org/10.1056/nejm197712012972201
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.