The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Risk of Cutaneous Carcinoma in Patients Treated with Oral Methoxsalen Photochemotherapy for Psoriasis
Abstract
A 2.1-year prospective study of 1373 patients given oral 8-methoxypsoralen photochemotherapy for psoriasis revealed 30 patients with a total of 48 basal-cell and squamous-cell carcinomas. The observed incidence of cutaneous carcinoma was 2.63 (95 per cent confidence limits = 1.91 to 3.90) times that expected for an age, sex and geographically matched population. Relative risk to patients with history of ionizing radiation was 3.68 (99 per cent confidence limits, 2.42 to 8.69). Patients with a previous cutaneous carcinoma had a relative risk of 10.22 (99 per cent confidence limits, 4.78 to 37.08). A higher than expected proportion of squamous-cell carcinomas and an excess of squamous-cell carcinomas in areas not exposed to sun were seen. New patients with known histories of ionizing-radiation exposure or of skin tumors should be given 8-methyoxypsoralen photochemotherapy only if they understand the risks and have disabling psoriasis untreatable by other means.
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Citations
Cites
Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light
Parrish, J. A., Fitzpatrick, T. B., Tanenbaum, L., & Pathak, M. A. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412052912301 · Cited by 1,376
Self-citation
Cited by
Squamous cell carcinoma of the skin (excluding lip and oral mucosa)
Johnson, T. M., Rowe, D. E., Nelson, B. R., & Swanson, N. A. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70074-p · Cited by 414
Psoralen and Ultraviolet A Light Therapy for Psoriasis
Stern, R. S. (2007) · New England Journal of Medicine · doi:10.1056/nejmct072317 · Cited by 149
Self-citationNickoloff, B. J. (2001) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2001.280201.x · Cited by 78
5-Methoxypsoralen: A Review of its Effects in Psoriasis and Vitiligo
McNeely, W., & Goa, K. L. (1998) · Drugs · doi:10.2165/00003495-199856040-00015 · Cited by 79
Darvekar, S., Juzenas, P., Oksvold, M., Kleinauskas, A., Holien, T., Christensen, E., Stokke, T., Sioud, M., & Peng, Q. (2020) · Cancers · doi:10.3390/cancers12020377 · Cited by 16
Metadata
- Authors
- Stern, R. S., Thibodeau, L. A., Kleinerman, R. A., Parrish, J. A., Fitzpatrick, T. B., & 22 Participating Investigators
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-04-12
- Volume
- 300
- Issue
- 15
- Pages
- 809-813
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2319891012
- Cited by
- 558
- References
- 1
- FWCI
- 77.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Risk of Cutaneous Carcinoma in Patients Treated with Oral Methoxsalen Photochemotherapy for Psoriasis. https://app.cochat.ai/papers/10.1056/nejm197904123001501
- The paper
- Stern, R. S., Thibodeau, L. A., Kleinerman, R. A., Parrish, J. A., Fitzpatrick, T. B., & 22 Participating Investigators. (1979). Risk of Cutaneous Carcinoma in Patients Treated with Oral Methoxsalen Photochemotherapy for Psoriasis. New England Journal of Medicine. https://doi.org/10.1056/nejm197904123001501
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
