Psoralen and Ultraviolet A Light Therapy for Psoriasis
Abstract
A 52-year-old man with psoriasis seeks treatment for his skin condition. Treatment with psoralen and ultraviolet A (PUVA) is recommended. PUVA has been used since the 1970s for the treatment of psoriasis, although few randomized studies and clinical trials comparing this treatment with no treatment or with other forms of treatment have been conducted. PUVA therapy increases the risks of both nonmelanoma skin cancer and melanoma.
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8-Methoxypsoralen and 5-methoxypsoralen are used in PUVA therapy for hyperproliferative skin diseases including psoriasis and vitiligo.
“Furocoumarins including bifunctional 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen (5-MOP) are still used in the so-called ''psoralen plus UVA (PUVA)'' therapy of rather frequent hyperproliferative skin diseases, including psoriasis and vitiligo (153-155).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [155]
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- Authors
- Stern, R. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Stern, Robert S.
- ORCID
- Stern, Robert S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-08-16
- Volume
- 357
- Issue
- 7
- Pages
- 682-690
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1989894409
- Cited by
- 149
- References
- 48
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 9
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Keywords
- psoriasis, psoralen, UVA, PUVA therapy, phototherapy, non-melanoma skin cancer, melanoma risk, treatment risks
- MeSH terms
- Ficusin, Humans, Male, Middle Aged, Psoriasis, PUVA Therapy, Skin, Photosensitizing Agents, Practice Guidelines as Topic
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